What compounds affect the Nervous system development pathway?

280 compounds in the BiohacksAI corpus have documented interactions with genes in the Nervous system development pathway (Reactome ID: R-HSA-9675108). These compounds target 156 genes within this pathway.

What genes are in the Nervous system development pathway?

The Nervous system development pathway involves 156 genes. Key genes include: ABL1, ABL2, ADAM10, ADRM1, APH1A, APH1B, ARHGAP35, BUB1B-PAK6, CACNA1C, CACNA1D.

Nervous system development

REACTOME PATHWAY

Reactome: R-HSA-9675108156 genes280 compounds

The Nervous system development pathway (Reactome ID: R-HSA-9675108) involves 156 genes and is affected by 280 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 ADAM10 ADRM1 APH1A APH1B ARHGAP35 BUB1B-PAK6 CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CDC42 CDK5 CDK5R1 CFL1 CREB1 CSNK2A1 CSNK2A2 CSNK2B CYP51A1 DPYSL2 EGFR EIF4G1 EPHA1 EPHA2 EPHA3 EPHA4+126 more

Compounds Affecting Nervous system development

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Crizotinib	—	298
5	Nocodazole Nocodazole is	—	215
6	Colchicine	—	300
7	Reserpine	—	297
8	kenpaullone	—	8
9	Podophyllotoxin	—	14
10	sp600125	—	117
11	Vorinostat	—	299
12	Vincristine	—	299
13	Noscapine	—	300
14	Quercetin	—	300
15	Demecolcine	—	246
16	Maytansine	—	300
17	vinblastine sulfate	—	81
18	alsterpaullone	—	12
19	Axitinib	—	298
20	tyrphostin ag 1478	—	4
21	fisetin	—	78
22	pictilisib	—	25
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	chrysin	—	300
26	Hexachlorophene	—	300
27	Saxitoxin	—	300
28	Afatinib	—	297
29	Kaempferols	—	300
30	ly294002	—	11
31	egcg	—	300
32	hydroxyfasudil [Supplementary Concept]	—	11
33	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
34	Quinidine	—	298
35	Veratridine	—	300
36	Genistein	—	300
37	Flunarizine Flunarizine is	—	299
38	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
39	Dihydroergocristine	—	187
40	Nisoldipine	—	297
41	Clotrimazole	—	296
42	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
43	Duloxetine Hydrochloride	—	993
44	Astemizole Antihistamine drug now withdrawn from	—	280
45	alpelisib	—	227
46	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
47	Sirolimus	—	300
48	cycloheximide	—	300
49	Dactinomycin	—	297
50	Ethidium	—	300

About the Nervous system development Pathway

The Nervous system development pathway is catalogued in Reactome (ID: R-HSA-9675108) and involves 156 genes. In the BiohacksAI corpus, 280 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, ADAM10, ADRM1, APH1A.