Question 1

What compounds affect the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway?

Accepted Answer

78 compounds in the BiohacksAI corpus have documented interactions with genes in the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway (Reactome ID: R-HSA-9856530). These compounds target 21 genes within this pathway.

Question 2

What genes are in the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway?

Accepted Answer

The High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway involves 21 genes. Key genes include: ADCY9, FLT4, FYN, GNAS, KDR, MAPKAP1, MLST8, MMP14, MTOR, NOS3.

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	torin 1	—	10
3	Ku 0063794 [Supplementary Concept]	—	7
4	pictilisib	—	25
5	ly294002	—	11
6	alpelisib	—	227
7	kenpaullone	—	8
8	hydroxyfasudil [Supplementary Concept]	—	11
9	Wortmannin	—	300
10	Sorafenib	—	300
11	Axitinib	—	298
12	Dasatinib	—	299
13	sp600125	—	117
14	alsterpaullone	—	12
15	Everolimus	—	297
16	Niclosamide	—	299
17	egcg	—	300
18	Disulfiram	—	297
19	Crizotinib	—	298
20	Resveratrol	—	298
21	Rotenone	—	300
22	Thapsigargin	—	300
23	amn082	—	29
24	Calcimycin	—	216
25	Idarubicin	—	299
26	Idazoxan	—	300
27	triolimus [Supplementary Concept]	—	33
28	tyrphostin 9	—	2
29	Ursolic Acid	—	300
30	Camptothecin	—	300
31	Dequalinium	—	136
32	Emetine	—	298
33	Epinephrine	—	299
34	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
35	Maprotiline	—	299
36	Perphenazine	—	297
37	Carmustine	—	297
38	Edaravone	—	298
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Iodoacetamide	—	300
41	Cisplatin	—	300
42	Cilostazol	—	297
43	Physostigmine	—	300
44	Ethylmaleimide	—	300
45	Physostigmine	—	299
46	tyrphostin 1	—	1
47	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
48	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
49	Aurintricarboxylic Acid	—	184
50	Diamide	—	300

BiohacksAI

High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

Genes in this Pathway

Compounds Affecting High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

About the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Pathway