What compounds affect the GPVI-mediated activation cascade pathway?

214 compounds in the BiohacksAI corpus have documented interactions with genes in the GPVI-mediated activation cascade pathway (Reactome ID: R-HSA-114604). These compounds target 16 genes within this pathway.

What genes are in the GPVI-mediated activation cascade pathway?

The GPVI-mediated activation cascade pathway involves 16 genes. Key genes include: CDC42, FYN, GP6, LAT, LCK, LYN, PDPK1, PIK3CB, PIK3CG, PIK3R1.

GPVI-mediated activation cascade

REACTOME PATHWAY

Reactome: R-HSA-11460416 genes214 compounds

The GPVI-mediated activation cascade pathway (Reactome ID: R-HSA-114604) involves 16 genes and is affected by 214 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC42 FYN GP6 LAT LCK LYN PDPK1 PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PRKCZ PTPN6 SYK

Compounds Affecting GPVI-mediated activation cascade

#	Compound	Targets Hit	Studies
1	ly294002	—	11
2	pictilisib	—	25
3	Sirolimus	—	300
4	Sorafenib	—	300
5	kenpaullone	—	8
6	Dasatinib	—	299
7	Crizotinib	—	298
8	sp600125	—	117
9	tyrphostin ag 1478	—	4
10	alpelisib	—	227
11	alsterpaullone	—	12
12	Wortmannin	—	300
13	torin 1	—	10
14	Quercetin	—	300
15	piceatannol	—	300
16	Axitinib	—	298
17	Afatinib	—	297
18	casin	—	10
19	celastrol	—	300
20	Acetic Acid Product of	—	300
21	Swainsonine	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Ouabain	—	300
24	Atorvastatin	—	1,000
25	Simvastatin	—	1,000
26	Methotrexate	—	289
27	Chlorhexidine	—	299
28	Clofarabine	—	298
29	Colchicine	—	300
30	cycloheximide	—	300
31	deguelin [Supplementary Concept]	—	151
32	Digoxin	—	299
33	Disulfiram	—	297
34	Emetine	—	298
35	Ezetimibe	—	296
36	Lovastatin	—	300
37	Medroxyprogesterone Acetate	—	299
38	Melphalan	—	300
39	Mometasone Furoate	—	292
40	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
41	Niclosamide	—	299
42	Podophyllotoxin	—	14
43	Thapsigargin	—	300
44	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
45	Trifluridine	—	295
46	fisetin	—	78
47	ag490	—	14
48	Azathioprine	—	300
49	Bortezomib	—	300
50	Maprotiline	—	299

About the GPVI-mediated activation cascade Pathway

The GPVI-mediated activation cascade pathway is catalogued in Reactome (ID: R-HSA-114604) and involves 16 genes. In the BiohacksAI corpus, 214 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, FYN, GP6, LAT, LCK.