What compounds affect the Cytokine Signaling in Immune system pathway?

600 compounds in the BiohacksAI corpus have documented interactions with genes in the Cytokine Signaling in Immune system pathway (Reactome ID: R-HSA-1280215). These compounds target 208 genes within this pathway.

What genes are in the Cytokine Signaling in Immune system pathway?

The Cytokine Signaling in Immune system pathway involves 208 genes. Key genes include: ABL2, ADAM17, ADRM1, AKT3, ALOX15, ALOX5, ANXA2, APP, ATF6, BCL2L1.

Cytokine Signaling in Immune system

REACTOME PATHWAY

Reactome: R-HSA-1280215208 genes600 compounds

The Cytokine Signaling in Immune system pathway (Reactome ID: R-HSA-1280215) involves 208 genes and is affected by 600 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL2 ADAM17 ADRM1 AKT3 ALOX15 ALOX5 ANXA2 APP ATF6 BCL2L1 BCL2L11 BIRC5 CA1 CAMK2B CAMK2D CASP1 CCL2 CDC42 CDK1 CFL1 CHUK CHURC1-FNTB CREB1 CSF1R CSK CTSG CUL1 CXCL8 DUSP3 EIF2AK2+178 more

Compounds Affecting Cytokine Signaling in Immune system

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Crizotinib	—	298
4	sp600125	—	117
5	Quercetin	—	300
6	Colchicine	—	300
7	Podophyllotoxin	—	14
8	vinblastine sulfate	—	81
9	Nocodazole Nocodazole is	—	215
10	Dasatinib	—	299
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Axitinib	—	298
13	Vincristine	—	299
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Reserpine	—	297
16	Noscapine	—	300
17	Demecolcine	—	246
18	Hexachlorophene	—	300
19	alsterpaullone	—	12
20	Disulfiram	—	297
21	Afatinib	—	297
22	kenpaullone	—	8
23	Vorinostat	—	299
24	cycloheximide	—	300
25	tyrphostin ag 1478	—	4
26	Maytansine	—	300
27	pictilisib	—	25
28	Kaempferols	—	300
29	Resveratrol	—	298
30	Methylene Blue	—	200
31	Masoprocol	—	300
32	Digoxin	—	299
33	withaferin	—	300
34	Camptothecin	—	300
35	Anisomycin	—	247
36	egcg	—	300
37	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
38	fisetin	—	78
39	celastrol	—	300
40	Lovastatin	—	300
41	Cladribine	—	297
42	Clotrimazole	—	296
43	Digitoxin	—	300
44	chrysin	—	300
45	Genistein	—	300
46	Tripterygium	—	300
47	Sertraline	—	1,000
48	Astemizole Antihistamine drug now withdrawn from	—	280
49	Daunorubicin	—	298
50	ly294002	—	11

About the Cytokine Signaling in Immune system Pathway

The Cytokine Signaling in Immune system pathway is catalogued in Reactome (ID: R-HSA-1280215) and involves 208 genes. In the BiohacksAI corpus, 600 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, ADAM17, ADRM1, AKT3, ALOX15.