What compounds affect the Toll-like Receptor Cascades pathway?

289 compounds in the BiohacksAI corpus have documented interactions with genes in the Toll-like Receptor Cascades pathway (Reactome ID: R-HSA-168898). These compounds target 55 genes within this pathway.

What genes are in the Toll-like Receptor Cascades pathway?

The Toll-like Receptor Cascades pathway involves 55 genes. Key genes include: APP, BTK, CHUK, CREB1, CTSL, CUL1, DUSP3, FOS, GSDMD, HMGB1.

Toll-like Receptor Cascades

REACTOME PATHWAY

Reactome: R-HSA-16889855 genes289 compounds

The Toll-like Receptor Cascades pathway (Reactome ID: R-HSA-168898) involves 55 genes and is affected by 289 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BTK CHUK CREB1 CTSL CUL1 DUSP3 FOS GSDMD HMGB1 HSP90B1 IKBKB IKBKE IRAK1 IRAK3 IRAK4 ITGB2 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8+25 more

Compounds Affecting Toll-like Receptor Cascades

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Crizotinib	—	298
3	sp600125	—	117
4	Disulfiram	—	297
5	Quercetin	—	300
6	Dasatinib	—	299
7	withaferin	—	300
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Axitinib	—	298
11	Afatinib	—	297
12	Anisomycin	—	247
13	Resveratrol	—	298
14	Oxyphenbutazone	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	fisetin	—	78
17	pictilisib	—	25
18	Bortezomib	—	300
19	Podophyllotoxin	—	14
20	Kaempferols	—	300
21	Trifluridine	—	295
22	plumbagin [Supplementary Concept]	—	300
23	cycloheximide	—	300
24	vinblastine sulfate	—	81
25	Digitoxin	—	300
26	Digoxin	—	299
27	pd98059	—	7
28	Adenosine Triphosphate	—	300
29	egcg	—	300
30	tyrphostin ag 1478	—	4
31	alsterpaullone	—	12
32	chicoric acid	—	117
33	Vemurafenib	—	298
34	Hexachlorophene	—	300
35	Methylene Blue	—	200
36	Cladribine	—	297
37	ninhydrin	—	300
38	Camptothecin	—	300
39	Genistein	—	300
40	daph	—	2
41	Clotrimazole	—	296
42	Thioridazine	—	35
43	Nisoldipine	—	297
44	Nocodazole Nocodazole is	—	215
45	Sertraline	—	1,000
46	2-Chloroadenosine 2-Chloroadenosine.	—	300
47	Salmeterol Xinafoate	—	227
48	Lovastatin	—	300
49	Masoprocol	—	300
50	Rutin	—	300

About the Toll-like Receptor Cascades Pathway

The Toll-like Receptor Cascades pathway is catalogued in Reactome (ID: R-HSA-168898) and involves 55 genes. In the BiohacksAI corpus, 289 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BTK, CHUK, CREB1, CTSL.