What compounds affect the Fc epsilon receptor (FCERI) signaling pathway?

299 compounds in the BiohacksAI corpus have documented interactions with genes in the Fc epsilon receptor (FCERI) signaling pathway (Reactome ID: R-HSA-2454202). These compounds target 60 genes within this pathway.

What genes are in the Fc epsilon receptor (FCERI) signaling pathway?

The Fc epsilon receptor (FCERI) signaling pathway involves 60 genes. Key genes include: ADRM1, BTK, CHUK, CUL1, FOS, FYN, GRB2, IKBKB, ITK, JUN.

Fc epsilon receptor (FCERI) signaling

REACTOME PATHWAY

Reactome: R-HSA-245420260 genes299 compounds

The Fc epsilon receptor (FCERI) signaling pathway (Reactome ID: R-HSA-2454202) involves 60 genes and is affected by 299 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BTK CHUK CUL1 FOS FYN GRB2 IKBKB ITK JUN LAT LYN MAP2K4 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NFKB1 NFKBIA PDPK1 PIK3CB PIK3R1 PIK3R2 PSMA1 PSMA2 PSMA3 PSMA4+30 more

Compounds Affecting Fc epsilon receptor (FCERI) signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	sp600125	—	117
5	Sorafenib	—	300
6	pictilisib	—	25
7	tyrphostin ag 1478	—	4
8	Quercetin	—	300
9	alsterpaullone	—	12
10	kenpaullone	—	8
11	withaferin	—	300
12	ly294002	—	11
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	Dasatinib	—	299
16	Disulfiram	—	297
17	Podophyllotoxin	—	14
18	Axitinib	—	298
19	egcg	—	300
20	Resveratrol	—	298
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	chicoric acid	—	117
23	Lovastatin	—	300
24	Trifluridine	—	295
25	fisetin	—	78
26	alpelisib	—	227
27	Sertraline	—	1,000
28	Afatinib	—	297
29	Clotrimazole	—	296
30	vinblastine sulfate	—	81
31	Kaempferols	—	300
32	daph	—	2
33	pd98059	—	7
34	plumbagin [Supplementary Concept]	—	300
35	Genistein	—	300
36	Anisomycin	—	247
37	Sirolimus	—	300
38	Chlorhexidine	—	299
39	Colchicine	—	300
40	Medroxyprogesterone Acetate	—	299
41	torin 1	—	10
42	Maprotiline	—	299
43	Nocodazole Nocodazole is	—	215
44	Vincristine	—	299
45	Methylene Blue	—	200
46	Ursolic Acid	—	300
47	Astemizole Antihistamine drug now withdrawn from	—	280
48	Cerulenin	—	300
49	Ethynodiol Diacetate	—	300
50	Hexachlorophene	—	300

About the Fc epsilon receptor (FCERI) signaling Pathway

The Fc epsilon receptor (FCERI) signaling pathway is catalogued in Reactome (ID: R-HSA-2454202) and involves 60 genes. In the BiohacksAI corpus, 299 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BTK, CHUK, CUL1, FOS.