What compounds affect the Phase 0 - rapid depolarisation pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Phase 0 - rapid depolarisation pathway (Reactome ID: R-HSA-5576892). These compounds target 12 genes within this pathway.

What genes are in the Phase 0 - rapid depolarisation pathway?

The Phase 0 - rapid depolarisation pathway involves 12 genes. Key genes include: CACNA1C, CACNA2D2, CAMK2B, CAMK2D, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A.

Phase 0 - rapid depolarisation

REACTOME PATHWAY

Reactome: R-HSA-557689212 genes62 compounds

The Phase 0 - rapid depolarisation pathway (Reactome ID: R-HSA-5576892) involves 12 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CACNA1C CACNA2D2 CAMK2B CAMK2D SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A

Compounds Affecting Phase 0 - rapid depolarisation

#	Compound	Targets Hit	Studies
1	Saxitoxin	—	300
2	Veratridine	—	300
3	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
4	Quinidine	—	298
5	Bupivacaine	—	300
6	Dibucaine	—	299
7	Lidocaine	—	299
8	Reserpine	—	297
9	Flunarizine Flunarizine is	—	299
10	Etidocaine	—	300
11	lidoflazine	—	278
12	Mianserin	—	299
13	Chlorpheniramine	—	298
14	Cinnarizine	—	299
15	Cyproheptadine	—	299
16	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
17	dilazep	—	300
18	Hydroxyzine	—	298
19	Lacosamide	—	297
20	Nortriptyline	—	295
21	Phenobarbital	—	297
22	Phentolamine	—	300
23	Promethazine	—	296
24	protriptyline	—	296
25	Aconitine	—	300
26	Nitrendipine	—	299
27	Nisoldipine	—	297
28	Duloxetine Hydrochloride	—	993
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
31	sp600125	—	117
32	Lamotrigine	—	296
33	Phenytoin	—	300
34	Riluzole	—	298
35	Amlodipine	—	1,000
36	Fluoxetine	—	1,000
37	Sertraline	—	1,000
38	Arachidonic Acid	—	245
39	Testosterone	—	299
40	Fluspirilene	—	74
41	cbd	—	298
42	Adapalene	—	296
43	cannabidiol	—	296
44	cgp37157	—	26
45	Clotrimazole	—	296
46	Crizotinib	—	298
47	Doripenem	—	298
48	Miconazole	—	298
49	Rimonabant	—	300
50	Troglitazone	—	299

About the Phase 0 - rapid depolarisation Pathway

The Phase 0 - rapid depolarisation pathway is catalogued in Reactome (ID: R-HSA-5576892) and involves 12 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1C, CACNA2D2, CAMK2B, CAMK2D, SCN1A.