What compounds affect the Mitotic Prometaphase pathway?

94 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitotic Prometaphase pathway (Reactome ID: R-HSA-68877). These compounds target 44 genes within this pathway.

What genes are in the Mitotic Prometaphase pathway?

The Mitotic Prometaphase pathway involves 44 genes. Key genes include: AURKB, BIRC5, CCNB1, CCNB2, CDK1, CSNK1D, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B.

Mitotic Prometaphase

REACTOME PATHWAY

Reactome: R-HSA-6887744 genes94 compounds

The Mitotic Prometaphase pathway (Reactome ID: R-HSA-68877) involves 44 genes and is affected by 94 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKB BIRC5 CCNB1 CCNB2 CDK1 CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B EML4 HDAC8 HSP90AA1 NEK2 NEK6 NEK7 NEK9 PLK1 PLK4 PPP1CC PPP2CA PPP2R5A PRKACA TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A+14 more

Compounds Affecting Mitotic Prometaphase

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vorinostat	—	299
4	Vincristine	—	299
5	Noscapine	—	300
6	Podophyllotoxin	—	14
7	Demecolcine	—	246
8	Maytansine	—	300
9	vinblastine sulfate	—	81
10	Quercetin	—	300
11	sp600125	—	117
12	fisetin	—	78
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Crizotinib	—	298
17	kenpaullone	—	8
18	alsterpaullone	—	12
19	chrysin	—	300
20	pictilisib	—	25
21	Sorafenib	—	300
22	Kaempferols	—	300
23	Dasatinib	—	299
24	ly294002	—	11
25	Axitinib	—	298
26	indirubin	—	300
27	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
28	Vanillic Acid	—	300
29	Okadaic Acid	—	300
30	Masoprocol	—	300
31	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
32	Clotrimazole	—	296
33	Disulfiram	—	297
34	Hexachlorophene	—	300
35	Idarubicin	—	299
36	Wortmannin	—	300
37	hydroxyfasudil [Supplementary Concept]	—	11
38	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
39	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
40	triolimus [Supplementary Concept]	—	33
41	monorden	—	8
42	gedunin	—	54
43	celastrol	—	300
44	Novobiocin	—	300
45	caffeic acid	—	300
46	Tetracycline	—	300
47	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
48	2-Chloroadenosine 2-Chloroadenosine.	—	300
49	ag490	—	14
50	Calcimycin	—	216

About the Mitotic Prometaphase Pathway

The Mitotic Prometaphase pathway is catalogued in Reactome (ID: R-HSA-68877) and involves 44 genes. In the BiohacksAI corpus, 94 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, CCNB1, CCNB2, CDK1.