What compounds affect the Transcriptional regulation by RUNX2 pathway?

527 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation by RUNX2 pathway (Reactome ID: R-HSA-8878166). These compounds target 57 genes within this pathway.

What genes are in the Transcriptional regulation by RUNX2 pathway?

The Transcriptional regulation by RUNX2 pathway involves 57 genes. Key genes include: ABL1, ADRM1, AKT3, AR, CBFB, CCNB1, CDK1, CDK4, CUL1, ESR1.

Transcriptional regulation by RUNX2

REACTOME PATHWAY

Reactome: R-HSA-887816657 genes527 compounds

The Transcriptional regulation by RUNX2 pathway (Reactome ID: R-HSA-8878166) involves 57 genes and is affected by 527 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AKT3 AR CBFB CCNB1 CDK1 CDK4 CUL1 ESR1 ESRRA GLI3 GSK3B HDAC3 HDAC4 HDAC6 MAPK1 MAPK3 NR3C1 PPM1D PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3+27 more

Compounds Affecting Transcriptional regulation by RUNX2

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Daunorubicin	—	298
4	Quercetin	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	chrysin	—	300
7	Genistein	—	300
8	Kaempferols	—	300
9	Celecoxib	—	295
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	kenpaullone	—	8
12	Disulfiram	—	297
13	Clotrimazole	—	296
14	Dasatinib	—	299
15	alsterpaullone	—	12
16	Sorafenib	—	300
17	Progesterone	—	299
18	Budesonide	—	1,000
19	cycloheximide	—	300
20	Ethidium	—	300
21	Dactinomycin	—	297
22	Hexachlorophene	—	300
23	Resveratrol	—	298
24	Rotenone	—	300
25	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
26	Emetine	—	298
27	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
28	Pueraria	—	300
29	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
30	Dihydrotestosterone	—	300
31	Testosterone	—	299
32	Spironolactone	—	298
33	Levonorgestrel	—	292
34	Norgestrel	—	300
35	Androstenedione	—	300
36	Ethinyl Estradiol	—	300
37	Testosterone Propionate	—	300
38	Lynestrenol	—	299
39	Methyltestosterone	—	300
40	Danazol	—	298
41	Estrone	—	300
42	Norethindrone	—	300
43	Ethynodiol Diacetate	—	300
44	Ouabain	—	300
45	Dehydroepiandrosterone	—	300
46	Dehydroepiandrosterone	—	300
47	Desoxycorticosterone	—	300
48	Digoxin	—	299
49	17-alpha-Hydroxyprogesterone	—	300
50	Azacitidine	—	298

About the Transcriptional regulation by RUNX2 Pathway

The Transcriptional regulation by RUNX2 pathway is catalogued in Reactome (ID: R-HSA-8878166) and involves 57 genes. In the BiohacksAI corpus, 527 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AKT3, AR, CBFB.