What compounds affect the ESR-mediated signaling pathway?

480 compounds in the BiohacksAI corpus have documented interactions with genes in the ESR-mediated signaling pathway (Reactome ID: R-HSA-8939211). These compounds target 49 genes within this pathway.

What genes are in the ESR-mediated signaling pathway?

The ESR-mediated signaling pathway involves 49 genes. Key genes include: AGO2, AKT3, CARM1, CBFB, CDK9, CREB1, CREBBP, EGFR, EP300, ERBB4.

ESR-mediated signaling

REACTOME PATHWAY

Reactome: R-HSA-893921149 genes480 compounds

The ESR-mediated signaling pathway (Reactome ID: R-HSA-8939211) involves 49 genes and is affected by 480 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AKT3 CARM1 CBFB CDK9 CREB1 CREBBP EGFR EP300 ERBB4 ESR1 ESR2 FKBP4 FKBP5 FOS FOXO3 GNAI1 HDAC1 HSP90AA1 HSP90AB1 HSPB1 IGF1R JUN KAT2B KDM1A KDM4B MAPK1 MAPK3 MMP7 MYC+19 more

Compounds Affecting ESR-mediated signaling

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	Ethidium	—	300
4	Disulfiram	—	297
5	Daunorubicin	—	298
6	cycloheximide	—	300
7	Clotrimazole	—	296
8	Nisoldipine	—	297
9	Dasatinib	—	299
10	alsterpaullone	—	12
11	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
12	Danazol	—	298
13	Bortezomib	—	300
14	vinblastine sulfate	—	81
15	Ciclopirox	—	88
16	Azacitidine	—	298
17	Azacitidine	—	300
18	Resveratrol	—	298
19	Ethinyl Estradiol	—	300
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Hexachlorophene	—	300
22	Progesterone	—	299
23	Toxaphene	—	299
24	Methylene Blue	—	200
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Lithocholic Acid	—	300
27	plumbagin [Supplementary Concept]	—	300
28	tyrphostin ag 1478	—	4
29	Sirolimus	—	300
30	Genistein	—	300
31	Dactinomycin	—	297
32	Rotenone	—	300
33	Dihydrotestosterone	—	300
34	Ethynodiol Diacetate	—	300
35	Mestranol	—	300
36	Oxymetholone	—	298
37	Testosterone Propionate	—	300
38	Lynestrenol	—	299
39	Phenoxybenzamine	—	21
40	Digoxin	—	299
41	Loratadine	—	296
42	chrysin	—	300
43	Testosterone	—	299
44	Emetine	—	298
45	Troglitazone	—	299
46	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
47	Promethazine	—	121
48	Stanozolol	—	300
49	triolimus [Supplementary Concept]	—	33
50	Budesonide	—	1,000

About the ESR-mediated signaling Pathway

The ESR-mediated signaling pathway is catalogued in Reactome (ID: R-HSA-8939211) and involves 49 genes. In the BiohacksAI corpus, 480 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AKT3, CARM1, CBFB, CDK9.