What genes are in the Signaling by Non-Receptor Tyrosine Kinases pathway?

The Signaling by Non-Receptor Tyrosine Kinases pathway involves 15 genes. Key genes include: ARHGAP35, CDK2, CDK4, EGFR, EPAS1, ERBB2, ERBB3, ERBB4, HIF1A, LRRK2.

Signaling by Non-Receptor Tyrosine Kinases

Q: What compounds affect the Signaling by Non-Receptor Tyrosine Kinases pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Non-Receptor Tyrosine Kinases pathway (Reactome ID: R-HSA-9006927). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-900692715 genes210 compounds

The Signaling by Non-Receptor Tyrosine Kinases pathway (Reactome ID: R-HSA-9006927) involves 15 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 CDK2 CDK4 EGFR EPAS1 ERBB2 ERBB3 ERBB4 HIF1A LRRK2 NR3C1 PTK6 PTPN1 SRMS STAT3

Compounds Affecting Signaling by Non-Receptor Tyrosine Kinases

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Afatinib	—	297
3	Hydrocortisone	—	299
4	Hydrocortisone	—	298
5	cycloheximide	—	300
6	Digoxin	—	299
7	Emetine	—	298
8	sp600125	—	117
9	tyrphostin ag 1478	—	4
10	Beclomethasone	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Desoximetasone	—	86
13	Lithocholic Acid	—	300
14	Mometasone Furoate	—	292
15	Quercetin	—	300
16	Clotrimazole	—	296
17	Nisoldipine	—	297
18	chrysin	—	300
19	Kaempferols	—	300
20	Celecoxib	—	295
21	oxatomide [Supplementary Concept] structure;	—	128
22	Phenoxybenzamine	—	21
23	triolimus [Supplementary Concept]	—	33
24	Topotecan	—	300
25	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Bortezomib	—	300
28	ag490	—	14
29	celastrol	—	300
30	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
32	gedunin	—	54
33	Niclosamide	—	299
34	Tubercidin	—	300
35	Prednisolone	—	1,000
36	Corticosterone	—	300
37	Budesonide	—	1,000
38	Triamcinolone Acetonide	—	300
39	Megestrol Acetate Megestrol acetate is	—	300
40	Methyltestosterone	—	300
41	Prednisone	—	298
42	Triamcinolone	—	300
43	Medroxyprogesterone Acetate	—	299
44	Methylprednisolone	—	299
45	Progesterone	—	299
46	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
47	Androstenedione	—	300
48	Azacitidine	—	298
49	Azacitidine	—	300
50	Betamethasone	—	299

About the Signaling by Non-Receptor Tyrosine Kinases Pathway

The Signaling by Non-Receptor Tyrosine Kinases pathway is catalogued in Reactome (ID: R-HSA-9006927) and involves 15 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CDK2, CDK4, EGFR, EPAS1.