What compounds affect the Signaling by Nuclear Receptors pathway?

536 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Nuclear Receptors pathway (Reactome ID: R-HSA-9006931). These compounds target 71 genes within this pathway.

What genes are in the Signaling by Nuclear Receptors pathway?

The Signaling by Nuclear Receptors pathway involves 71 genes. Key genes include: AGO2, AKR1C3, AKT3, ALDH1A1, CARM1, CBFB, CDK9, CREB1, CREBBP, DLD.

Signaling by Nuclear Receptors

REACTOME PATHWAY

Reactome: R-HSA-900693171 genes536 compounds

The Signaling by Nuclear Receptors pathway (Reactome ID: R-HSA-9006931) involves 71 genes and is affected by 536 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AKR1C3 AKT3 ALDH1A1 CARM1 CBFB CDK9 CREB1 CREBBP DLD EGFR EP300 ERBB4 ESR1 ESR2 FABP5 FASN FKBP4 FKBP5 FOS FOXO3 GNAI1 HDAC1 HDAC3 HSP90AA1 HSP90AB1 HSPB1 IGF1R JUN KAT2B+41 more

Compounds Affecting Signaling by Nuclear Receptors

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Ethidium	—	300
3	Quercetin	—	300
4	Daunorubicin	—	298
5	Progesterone	—	299
6	Masoprocol	—	300
7	cycloheximide	—	300
8	Bortezomib	—	300
9	Clotrimazole	—	296
10	Dasatinib	—	299
11	Hexachlorophene	—	300
12	Nisoldipine	—	297
13	Ethinyl Estradiol	—	300
14	Genistein	—	300
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
16	Dactinomycin	—	297
17	Danazol	—	298
18	Rotenone	—	300
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	vinblastine sulfate	—	81
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Gemfibrozil	—	297
24	Calcitriol	—	300
25	alsterpaullone	—	12
26	Resveratrol	—	298
27	Dihydrotestosterone	—	300
28	Loratadine	—	296
29	Adapalene	—	296
30	Ciclopirox	—	88
31	Toxaphene	—	299
32	chrysin	—	300
33	Testosterone	—	299
34	Promethazine	—	121
35	Methylene Blue	—	200
36	Lithocholic Acid	—	300
37	Ethynodiol Diacetate	—	300
38	Flutamide	—	298
39	Oxymetholone	—	298
40	Testosterone Propionate	—	300
41	Lynestrenol	—	299
42	Vitamin	—	295
43	Niclosamide	—	299
44	Triiodothyronine	—	300
45	Celecoxib	—	295
46	Chlorhexidine	—	299
47	Retinaldehyde	—	300
48	Emetine	—	298
49	Vitamin K 3	—	300
50	Spironolactone	—	298

About the Signaling by Nuclear Receptors Pathway

The Signaling by Nuclear Receptors pathway is catalogued in Reactome (ID: R-HSA-9006931) and involves 71 genes. In the BiohacksAI corpus, 536 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AKR1C3, AKT3, ALDH1A1, CARM1.