What compounds affect the Interferon Signaling pathway?

293 compounds in the BiohacksAI corpus have documented interactions with genes in the Interferon Signaling pathway (Reactome ID: R-HSA-913531). These compounds target 69 genes within this pathway.

What genes are in the Interferon Signaling pathway?

The Interferon Signaling pathway involves 69 genes. Key genes include: ATF6, CAMK2B, CAMK2D, CASP1, CDK1, CHUK, CHURC1-FNTB, EIF2AK2, EIF2AK3, EIF4A1.

Interferon Signaling

REACTOME PATHWAY

Reactome: R-HSA-91353169 genes293 compounds

The Interferon Signaling pathway (Reactome ID: R-HSA-913531) involves 69 genes and is affected by 293 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATF6 CAMK2B CAMK2D CASP1 CDK1 CHUK CHURC1-FNTB EIF2AK2 EIF2AK3 EIF4A1 EIF4G1 FKBP5 FNTA FNTB FURIN HLA-A HLA-B HSPA1A HSPA1B HSPA5 HSPA8 ICAM1 IFNB1 IFNG IKBKB JAK2 KPNB1 MAPK1 MAPK3 NPM1+39 more

Compounds Affecting Interferon Signaling

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	vinblastine sulfate	—	81
4	Noscapine	—	300
5	Vincristine	—	299
6	Podophyllotoxin	—	14
7	Vorinostat	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	sp600125	—	117
11	Hexachlorophene	—	300
12	Sorafenib	—	300
13	celastrol	—	300
14	Crizotinib	—	298
15	alsterpaullone	—	12
16	Bortezomib	—	300
17	Quercetin	—	300
18	Camptothecin	—	300
19	kenpaullone	—	8
20	Methylene Blue	—	200
21	cycloheximide	—	300
22	Sertraline	—	1,000
23	Astemizole Antihistamine drug now withdrawn from	—	280
24	Tripterygium	—	300
25	withaferin	—	300
26	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
27	Lovastatin	—	300
28	Dactinomycin	—	297
29	Daunorubicin	—	298
30	Disulfiram	—	297
31	Axitinib	—	298
32	Genistein	—	300
33	Clotrimazole	—	296
34	Thioridazine	—	35
35	Idarubicin	—	299
36	Chlorhexidine	—	299
37	Dasatinib	—	299
38	Calcimycin	—	216
39	Lithocholic Acid	—	300
40	Okadaic Acid	—	300
41	Ergosterol	—	300
42	Ethinyl Estradiol	—	300
43	Azacitidine	—	298
44	Azacitidine	—	300
45	Azathioprine	—	300
46	Cladribine	—	297
47	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
48	Cytarabine	—	297
49	Niclosamide	—	299
50	Methotrexate	—	289

About the Interferon Signaling Pathway

The Interferon Signaling pathway is catalogued in Reactome (ID: R-HSA-913531) and involves 69 genes. In the BiohacksAI corpus, 293 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATF6, CAMK2B, CAMK2D, CASP1, CDK1.