What compounds affect the SARS-CoV-2 Infection pathway?

164 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-2 Infection pathway (Reactome ID: R-HSA-9694516). These compounds target 42 genes within this pathway.

What genes are in the SARS-CoV-2 Infection pathway?

The SARS-CoV-2 Infection pathway involves 42 genes. Key genes include: AKT3, CHUK, CREBBP, CSNK1A1, CTSL, FURIN, GALNT1, GANAB, GSK3A, GSK3B.

SARS-CoV-2 Infection

REACTOME PATHWAY

Reactome: R-HSA-969451642 genes164 compounds

The SARS-CoV-2 Infection pathway (Reactome ID: R-HSA-9694516) involves 42 genes and is affected by 164 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CHUK CREBBP CSNK1A1 CTSL FURIN GALNT1 GANAB GSK3A GSK3B HLA-A HLA-B HSP90AA1 HSP90AB1 IFNB1 IKBKB IKBKE IRAK1 MAN2A1 MAP1LC3B MAP3K7 NLRP3 NOD1 NOD2 PDPK1 PIK3C3 PRMT1 PTPN6 RIPK2 RPSA+12 more

Compounds Affecting SARS-CoV-2 Infection

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	sp600125	—	117
4	Disulfiram	—	297
5	cycloheximide	—	300
6	kenpaullone	—	8
7	Hexachlorophene	—	300
8	celastrol	—	300
9	Idarubicin	—	299
10	Calcimycin	—	216
11	Quercetin	—	300
12	alsterpaullone	—	12
13	Axitinib	—	298
14	Camptothecin	—	300
15	Ouabain	—	300
16	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
17	Digitoxin	—	300
18	Digoxin	—	299
19	triolimus [Supplementary Concept]	—	33
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	piceatannol	—	300
24	egcg	—	300
25	Bortezomib	—	300
26	Tripterygium	—	300
27	Leflunomide	—	297
28	Genistein	—	300
29	Sertraline	—	1,000
30	Afatinib	—	297
31	Novobiocin	—	300
32	Masoprocol	—	300
33	Calcitriol	—	300
34	Niclosamide	—	299
35	Anisomycin	—	247
36	Chlorhexidine	—	299
37	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
38	chrysin	—	300
39	withaferin	—	300
40	Emetine	—	298
41	Proscillaridin	—	219
42	Dactinomycin	—	297
43	Daunorubicin	—	298
44	Epirubicin	—	300
45	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
46	Azacitidine	—	298
47	Azacitidine	—	300
48	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
49	cbd	—	298
50	cannabidiol	—	296

About the SARS-CoV-2 Infection Pathway

The SARS-CoV-2 Infection pathway is catalogued in Reactome (ID: R-HSA-9694516) and involves 42 genes. In the BiohacksAI corpus, 164 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CHUK, CREBBP, CSNK1A1, CTSL.