What compounds affect the Signaling by NTRKs pathway?

121 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NTRKs pathway (Reactome ID: R-HSA-166520). These compounds target 40 genes within this pathway.

What genes are in the Signaling by NTRKs pathway?

The Signaling by NTRKs pathway involves 40 genes. Key genes include: BRAF, CDK5, CDK5R1, CREB1, DUSP3, EP300, F3, FOS, FURIN, FYN.

Signaling by NTRKs

REACTOME PATHWAY

Reactome: R-HSA-16652040 genes121 compounds

The Signaling by NTRKs pathway (Reactome ID: R-HSA-166520) involves 40 genes and is affected by 121 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF CDK5 CDK5R1 CREB1 DUSP3 EP300 F3 FOS FURIN FYN GRB2 GRIN2B ID4 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAPK2 NTRK1 NTRK2 NTRK3 PIK3CB PIK3R1 PIK3R2+10 more

Compounds Affecting Signaling by NTRKs

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Dasatinib	—	299
4	fisetin	—	78
5	Quercetin	—	300
6	kenpaullone	—	8
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	withaferin	—	300
9	Crizotinib	—	298
10	alsterpaullone	—	12
11	egcg	—	300
12	Afatinib	—	297
13	pictilisib	—	25
14	pd98059	—	7
15	tyrphostin ag 1478	—	4
16	trametinib	—	296
17	hydroxyfasudil [Supplementary Concept]	—	11
18	Anisomycin	—	247
19	Axitinib	—	298
20	Vemurafenib	—	298
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	chrysin	—	300
23	plumbagin [Supplementary Concept]	—	300
24	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
25	Resveratrol	—	298
26	ly294002	—	11
27	Sirolimus	—	300
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	Dactinomycin	—	297
30	Ethidium	—	300
31	trequinsin hydrochloride	—	1
32	Genistein	—	300
33	Masoprocol	—	300
34	indirubin	—	300
35	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
36	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
37	Celecoxib	—	295
38	Niclosamide	—	299
39	Wortmannin	—	300
40	alpelisib	—	227
41	Oleanolic Acid	—	300
42	cycloheximide	—	300
43	Disulfiram	—	297
44	Azacitidine	—	298
45	Azacitidine	—	300
46	Levalbuterol	—	1,000
47	Levalbuterol	—	297
48	Bortezomib	—	300
49	Clofarabine	—	298
50	Danazol	—	298

About the Signaling by NTRKs Pathway

The Signaling by NTRKs pathway is catalogued in Reactome (ID: R-HSA-166520) and involves 40 genes. In the BiohacksAI corpus, 121 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, CDK5, CDK5R1, CREB1, DUSP3.