What compounds affect the Toll Like Receptor 3 (TLR3) Cascade pathway?

285 compounds in the BiohacksAI corpus have documented interactions with genes in the Toll Like Receptor 3 (TLR3) Cascade pathway (Reactome ID: R-HSA-168164). These compounds target 43 genes within this pathway.

What genes are in the Toll Like Receptor 3 (TLR3) Cascade pathway?

The Toll Like Receptor 3 (TLR3) Cascade pathway involves 43 genes. Key genes include: APP, CHUK, CREB1, CUL1, DUSP3, FOS, HMGB1, IKBKB, IKBKE, IRAK1.

Toll Like Receptor 3 (TLR3) Cascade

REACTOME PATHWAY

Reactome: R-HSA-16816443 genes285 compounds

The Toll Like Receptor 3 (TLR3) Cascade pathway (Reactome ID: R-HSA-168164) involves 43 genes and is affected by 285 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK CREB1 CUL1 DUSP3 FOS HMGB1 IKBKB IKBKE IRAK1 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NFKB2 NFKBIA NOD1 NOD2 PPP2CA+13 more

Compounds Affecting Toll Like Receptor 3 (TLR3) Cascade

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Quercetin	—	300
4	withaferin	—	300
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Crizotinib	—	298
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Disulfiram	—	297
9	Axitinib	—	298
10	Afatinib	—	297
11	Anisomycin	—	247
12	Resveratrol	—	298
13	Dasatinib	—	299
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	fisetin	—	78
16	Bortezomib	—	300
17	Oxyphenbutazone	—	300
18	Podophyllotoxin	—	14
19	Kaempferols	—	300
20	Trifluridine	—	295
21	plumbagin [Supplementary Concept]	—	300
22	cycloheximide	—	300
23	vinblastine sulfate	—	81
24	Digitoxin	—	300
25	Digoxin	—	299
26	pd98059	—	7
27	egcg	—	300
28	alsterpaullone	—	12
29	chicoric acid	—	117
30	pictilisib	—	25
31	Vemurafenib	—	298
32	Hexachlorophene	—	300
33	Methylene Blue	—	200
34	Cladribine	—	297
35	ninhydrin	—	300
36	Camptothecin	—	300
37	Genistein	—	300
38	daph	—	2
39	Clotrimazole	—	296
40	Thioridazine	—	35
41	Nisoldipine	—	297
42	Nocodazole Nocodazole is	—	215
43	Sertraline	—	1,000
44	Adenosine Triphosphate	—	300
45	Salmeterol Xinafoate	—	227
46	Masoprocol	—	300
47	Rutin	—	300
48	Withania	—	500
49	tamarixetin	—	26
50	tyrphostin ag 1478	—	4

About the Toll Like Receptor 3 (TLR3) Cascade Pathway

The Toll Like Receptor 3 (TLR3) Cascade pathway is catalogued in Reactome (ID: R-HSA-168164) and involves 43 genes. In the BiohacksAI corpus, 285 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, CREB1, CUL1, DUSP3.