What compounds affect the Oxidative Stress Induced Senescence pathway?

250 compounds in the BiohacksAI corpus have documented interactions with genes in the Oxidative Stress Induced Senescence pathway (Reactome ID: R-HSA-2559580). These compounds target 26 genes within this pathway.

What genes are in the Oxidative Stress Induced Senescence pathway?

The Oxidative Stress Induced Senescence pathway involves 26 genes. Key genes include: CDK4, CDK6, EED, EZH2, FOS, IFNB1, JUN, KDM6B, MAP2K3, MAP2K4.

Oxidative Stress Induced Senescence

REACTOME PATHWAY

Reactome: R-HSA-255958026 genes250 compounds

The Oxidative Stress Induced Senescence pathway (Reactome ID: R-HSA-2559580) involves 26 genes and is affected by 250 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK4 CDK6 EED EZH2 FOS IFNB1 JUN KDM6B MAP2K3 MAP2K4 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK5 MDM2 MDM4 MINK1 TNIK TP53

Compounds Affecting Oxidative Stress Induced Senescence

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Sorafenib	—	300
3	Anisomycin	—	247
4	Axitinib	—	298
5	withaferin	—	300
6	Afatinib	—	297
7	Methylene Blue	—	200
8	Quercetin	—	300
9	Sertraline	—	1,000
10	Dasatinib	—	299
11	fisetin	—	78
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	Azacitidine	—	298
14	Azacitidine	—	300
15	cycloheximide	—	300
16	Thioridazine	—	35
17	vinblastine sulfate	—	81
18	Digoxin	—	299
19	Nisoldipine	—	297
20	Nocodazole Nocodazole is	—	215
21	Oxyphenbutazone	—	300
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Colchicine	—	300
24	Calcimycin	—	216
25	cardamonin	—	180
26	alsterpaullone	—	12
27	Hexachlorophene	—	300
28	Cladribine	—	297
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	Cytarabine	—	297
31	Melphalan	—	300
32	Niclosamide	—	299
33	Methotrexate	—	289
34	Disulfiram	—	297
35	Trifluridine	—	295
36	plumbagin [Supplementary Concept]	—	300
37	Genistein	—	300
38	Ciclopirox	—	88
39	Dinitrochlorobenzene	—	300
40	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
41	Vorinostat	—	299
42	Clotrimazole	—	296
43	Spironolactone	—	298
44	pd98059	—	7
45	rafoxanide	—	172
46	triolimus [Supplementary Concept]	—	33
47	Chlorhexidine	—	299
48	Demecolcine	—	246
49	tyrphostin 9	—	2
50	egcg	—	300

About the Oxidative Stress Induced Senescence Pathway

The Oxidative Stress Induced Senescence pathway is catalogued in Reactome (ID: R-HSA-2559580) and involves 26 genes. In the BiohacksAI corpus, 250 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK4, CDK6, EED, EZH2, FOS.