What compounds affect the L1CAM interactions pathway?

101 compounds in the BiohacksAI corpus have documented interactions with genes in the L1CAM interactions pathway (Reactome ID: R-HSA-373760). These compounds target 48 genes within this pathway.

What genes are in the L1CAM interactions pathway?

The L1CAM interactions pathway involves 48 genes. Key genes include: CSNK2A1, CSNK2A2, CSNK2B, DPYSL2, EGFR, EPHB2, FGFR1, HSPA8, ITGA2B, ITGAV.

L1CAM interactions

REACTOME PATHWAY

Reactome: R-HSA-37376048 genes101 compounds

The L1CAM interactions pathway (Reactome ID: R-HSA-373760) involves 48 genes and is affected by 101 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK2A1 CSNK2A2 CSNK2B DPYSL2 EGFR EPHB2 FGFR1 HSPA8 ITGA2B ITGAV ITGB3 LYPLA2 MAP2K1 MAP2K2 MAPK1 MAPK3 NRP2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KA6 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A+18 more

Compounds Affecting L1CAM interactions

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Saxitoxin	—	300
11	Sorafenib	—	300
12	Veratridine	—	300
13	fisetin	—	78
14	sp600125	—	117
15	Dasatinib	—	299
16	alsterpaullone	—	12
17	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
18	Bupivacaine	—	300
19	Dibucaine	—	299
20	Lidocaine	—	299
21	Quinidine	—	298
22	pd98059	—	7
23	kenpaullone	—	8
24	trametinib	—	296
25	Quercetin	—	300
26	Kaempferols	—	300
27	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
28	Axitinib	—	298
29	Flunarizine Flunarizine is	—	299
30	Etidocaine	—	300
31	lidoflazine	—	278
32	Mianserin	—	299
33	Chlorpheniramine	—	298
34	Cinnarizine	—	299
35	Cyproheptadine	—	299
36	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
37	dilazep	—	300
38	Hydroxyzine	—	298
39	Lacosamide	—	297
40	Nortriptyline	—	295
41	Phenobarbital	—	297
42	Phentolamine	—	300
43	Promethazine	—	296
44	protriptyline	—	296
45	Reserpine	—	297
46	tyrphostin ag 1478	—	4
47	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
50	chrysin	—	300

About the L1CAM interactions Pathway

The L1CAM interactions pathway is catalogued in Reactome (ID: R-HSA-373760) and involves 48 genes. In the BiohacksAI corpus, 101 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK2A1, CSNK2A2, CSNK2B, DPYSL2, EGFR.