What compounds affect the Histamine receptors pathway?

79 compounds in the BiohacksAI corpus have documented interactions with genes in the Histamine receptors pathway (Reactome ID: R-HSA-390650). These compounds target 4 genes within this pathway.

What genes are in the Histamine receptors pathway?

The Histamine receptors pathway involves 4 genes. Key genes include: HRH1, HRH2, HRH3, HRH4.

Histamine receptors

REACTOME PATHWAY

Reactome: R-HSA-3906504 genes79 compounds

The Histamine receptors pathway (Reactome ID: R-HSA-390650) involves 4 genes and is affected by 79 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HRH1 HRH2 HRH3 HRH4

Compounds Affecting Histamine receptors

#	Compound	Targets Hit	Studies
1	Histamine	—	300
2	Impromidine	—	300
3	Metergoline	—	144
4	Aripiprazole	—	298
5	Astemizole Antihistamine drug now withdrawn from	—	280
6	Loxapine	—	225
7	Amoxapine	—	259
8	Fluoxetine	—	1,000
9	Pramipexole	—	297
10	Burimamide	—	237
11	Cetirizine	—	296
12	Chlorpheniramine	—	298
13	Quetiapine Fumarate	—	994
14	Loratadine	—	296
15	Mianserin	—	299
16	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
17	Hydroxyzine	—	298
18	Promethazine	—	296
19	Venlafaxine Hydrochloride	—	1,000
20	Cabergoline	—	299
21	Meclizine	—	121
22	Methylergonovine	—	193
23	Methysergide	—	300
24	Pergolide	—	299
25	Dimaprit	—	300
26	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
27	Aprindine	—	300
28	Cyproheptadine	—	299
29	Fluspirilene	—	74
30	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
31	Maprotiline	—	299
32	Nortriptyline	—	295
33	oxatomide [Supplementary Concept] structure;	—	128
34	Perphenazine	—	297
35	Tolterodine Tartrate	—	73
36	Trazodone	—	297
37	Acetylcarnitine	—	300
38	Duloxetine Hydrochloride	—	993
39	Sirolimus	—	300
40	amn082	—	29
41	Antazoline	—	229
42	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
43	Cinnarizine	—	299
44	Cyclizine	—	251
45	Dimethindene	—	119
46	Domperidone	—	299
47	hydroxyfasudil [Supplementary Concept]	—	11
48	Hyoscyamine	—	296
49	Idarubicin	—	299
50	lidoflazine	—	278

About the Histamine receptors Pathway

The Histamine receptors pathway is catalogued in Reactome (ID: R-HSA-390650) and involves 4 genes. In the BiohacksAI corpus, 79 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HRH1, HRH2, HRH3, HRH4.