What compounds affect the Adrenoceptors pathway?

206 compounds in the BiohacksAI corpus have documented interactions with genes in the Adrenoceptors pathway (Reactome ID: R-HSA-390696). These compounds target 9 genes within this pathway.

What genes are in the Adrenoceptors pathway?

The Adrenoceptors pathway involves 9 genes. Key genes include: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3.

Adrenoceptors

REACTOME PATHWAY

Reactome: R-HSA-3906969 genes206 compounds

The Adrenoceptors pathway (Reactome ID: R-HSA-390696) involves 9 genes and is affected by 206 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3

Compounds Affecting Adrenoceptors

#	Compound	Targets Hit	Studies
1	Norepinephrine Precursor of epinephrine that is secreted by	—	298
2	Aripiprazole	—	298
3	Epinephrine	—	299
4	Phenylephrine	—	299
5	Carvedilol	—	296
6	Tamsulosin	—	298
7	Dihydroergotamine	—	299
8	Yohimbine	—	299
9	Loxapine	—	225
10	Lisuride	—	299
11	Dihydroergotamine	—	9
12	Phentolamine	—	300
13	Idazoxan	—	300
14	Clonidine	—	299
15	Mianserin	—	299
16	Oxymetazoline	—	298
17	Quetiapine Fumarate	—	994
18	Buspirone	—	299
19	Piperoxan	—	167
20	Fluoxetine	—	1,000
21	Indoramin	—	250
22	Naphazoline	—	298
23	Methoxamine	—	300
24	Hydroxyzine	—	298
25	Tolazoline	—	300
26	Trazodone	—	297
27	Amlodipine	—	1,000
28	Bromocriptine	—	299
29	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
30	Nylidrin	—	90
31	Pergolide	—	299
32	Chlorhexidine	—	299
33	Guanabenz	—	298
34	Metergoline	—	144
35	Phenoxybenzamine	—	21
36	Atenolol	—	297
37	Dexmedetomidine	—	299
38	Labetalol	—	295
39	Nebivolol	—	297
40	Amoxapine	—	259
41	Nortriptyline	—	295
42	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
43	Maprotiline	—	299
44	Perphenazine	—	297
45	Ranolazine	—	297
46	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
47	Astemizole Antihistamine drug now withdrawn from	—	280
48	Cabergoline	—	299
49	Promethazine	—	296
50	Rilmenidine Oxazole derivative that acts as	—	300

About the Adrenoceptors Pathway

The Adrenoceptors pathway is catalogued in Reactome (ID: R-HSA-390696) and involves 9 genes. In the BiohacksAI corpus, 206 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B.