What compounds affect the Signaling by Interleukins pathway?

576 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Interleukins pathway (Reactome ID: R-HSA-449147). These compounds target 149 genes within this pathway.

What genes are in the Signaling by Interleukins pathway?

The Signaling by Interleukins pathway involves 149 genes. Key genes include: ADRM1, ALOX15, ALOX5, ANXA2, APP, BCL2L1, BIRC5, CA1, CASP1, CCL2.

Signaling by Interleukins

REACTOME PATHWAY

Reactome: R-HSA-449147149 genes576 compounds

The Signaling by Interleukins pathway (Reactome ID: R-HSA-449147) involves 149 genes and is affected by 576 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ALOX15 ALOX5 ANXA2 APP BCL2L1 BIRC5 CA1 CASP1 CCL2 CDC42 CFL1 CHUK CREB1 CSF1R CTSG CUL1 CXCL8 DUSP3 F13A1 FOS FOXO3 FPR1 FYN GRB2 GSDMD GSTO1 HCK HIF1A HMGB1+119 more

Compounds Affecting Signaling by Interleukins

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Quercetin	—	300
4	Crizotinib	—	298
5	sp600125	—	117
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Dasatinib	—	299
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Axitinib	—	298
10	Reserpine	—	297
11	Disulfiram	—	297
12	Hexachlorophene	—	300
13	alsterpaullone	—	12
14	Afatinib	—	297
15	pictilisib	—	25
16	Resveratrol	—	298
17	cycloheximide	—	300
18	Kaempferols	—	300
19	tyrphostin ag 1478	—	4
20	Methylene Blue	—	200
21	kenpaullone	—	8
22	Anisomycin	—	247
23	egcg	—	300
24	Masoprocol	—	300
25	Digoxin	—	299
26	Podophyllotoxin	—	14
27	fisetin	—	78
28	withaferin	—	300
29	Cladribine	—	297
30	vinblastine sulfate	—	81
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Camptothecin	—	300
33	Clotrimazole	—	296
34	ly294002	—	11
35	chrysin	—	300
36	Celecoxib	—	295
37	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
38	Colchicine	—	300
39	Trifluridine	—	295
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Digitoxin	—	300
42	Ethinyl Estradiol	—	300
43	Nisoldipine	—	297
44	Tetracycline	—	300
45	Oxyphenbutazone	—	300
46	Sirolimus	—	300
47	Methotrexate	—	289
48	Niclosamide	—	299
49	Nocodazole Nocodazole is	—	215
50	Tripterygium	—	300

About the Signaling by Interleukins Pathway

The Signaling by Interleukins pathway is catalogued in Reactome (ID: R-HSA-449147) and involves 149 genes. In the BiohacksAI corpus, 576 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ALOX15, ALOX5, ANXA2, APP.