What compounds affect the Interleukin-2 family signaling pathway?

218 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-2 family signaling pathway (Reactome ID: R-HSA-451927). These compounds target 19 genes within this pathway.

What genes are in the Interleukin-2 family signaling pathway?

The Interleukin-2 family signaling pathway involves 19 genes. Key genes include: GRB2, IL15, IL15RA, IL3, INPPL1, JAK2, JAK3, LCK, PIK3CB, PIK3CD.

Interleukin-2 family signaling

REACTOME PATHWAY

Reactome: R-HSA-45192719 genes218 compounds

The Interleukin-2 family signaling pathway (Reactome ID: R-HSA-451927) involves 19 genes and is affected by 218 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 IL15 IL15RA IL3 INPPL1 JAK2 JAK3 LCK PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTK2B PTPN6 STAT1 STAT3 STAT5A SYK

Compounds Affecting Interleukin-2 family signaling

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	ly294002	—	11
3	pictilisib	—	25
4	Sorafenib	—	300
5	Sirolimus	—	300
6	alpelisib	—	227
7	Dasatinib	—	299
8	sp600125	—	117
9	torin 1	—	10
10	Axitinib	—	298
11	Methylene Blue	—	200
12	Afatinib	—	297
13	Wortmannin	—	300
14	Methotrexate	—	289
15	cycloheximide	—	300
16	Niclosamide	—	299
17	piceatannol	—	300
18	Podophyllotoxin	—	14
19	Trifluridine	—	295
20	tyrphostin ag 1478	—	4
21	Azathioprine	—	300
22	Tripterygium	—	300
23	2-Methoxyestradiol	—	300
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Calcitriol	—	300
26	Camptothecin	—	300
27	celastrol	—	300
28	Cladribine	—	297
29	Hexachlorophene	—	300
30	Quercetin	—	300
31	Cytarabine	—	297
32	kenpaullone	—	8
33	Ku 0063794 [Supplementary Concept]	—	7
34	streptonigrin	—	299
35	Cefazolin	—	300
36	Ouabain	—	300
37	Atorvastatin	—	1,000
38	Simvastatin	—	1,000
39	Chlorhexidine	—	299
40	Clofarabine	—	298
41	Colchicine	—	300
42	deguelin [Supplementary Concept]	—	151
43	Digoxin	—	299
44	Disulfiram	—	297
45	Emetine	—	298
46	Ezetimibe	—	296
47	Lovastatin	—	300
48	Medroxyprogesterone Acetate	—	299
49	Melphalan	—	300
50	Mometasone Furoate	—	292

About the Interleukin-2 family signaling Pathway

The Interleukin-2 family signaling pathway is catalogued in Reactome (ID: R-HSA-451927) and involves 19 genes. In the BiohacksAI corpus, 218 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, IL15, IL15RA, IL3, INPPL1.