What compounds affect the Platelet Aggregation (Plug Formation) pathway?

324 compounds in the BiohacksAI corpus have documented interactions with genes in the Platelet Aggregation (Plug Formation) pathway (Reactome ID: R-HSA-76009). These compounds target 14 genes within this pathway.

What genes are in the Platelet Aggregation (Plug Formation) pathway?

The Platelet Aggregation (Plug Formation) pathway involves 14 genes. Key genes include: ADRA2A, ADRA2B, ADRA2C, CSK, GRB2, ITGA2B, ITGB3, PDPK1, PTPN1, RAPGEF3.

Platelet Aggregation (Plug Formation)

REACTOME PATHWAY

Reactome: R-HSA-7600914 genes324 compounds

The Platelet Aggregation (Plug Formation) pathway (Reactome ID: R-HSA-76009) involves 14 genes and is affected by 324 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA2A ADRA2B ADRA2C CSK GRB2 ITGA2B ITGB3 PDPK1 PTPN1 RAPGEF3 RAPGEF4 SRC SYK THPO

Compounds Affecting Platelet Aggregation (Plug Formation)

#	Compound	Targets Hit	Studies
1	Perphenazine	—	297
2	Amoxapine	—	259
3	Metergoline	—	144
4	Chlorhexidine	—	299
5	Niclosamide	—	299
6	Maprotiline	—	299
7	Aripiprazole	—	298
8	lidoflazine	—	278
9	Nortriptyline	—	295
10	Fluoxetine	—	1,000
11	Buspirone	—	299
12	Idarubicin	—	299
13	kenpaullone	—	8
14	Methysergide	—	300
15	Pramipexole	—	297
16	Bromocriptine	—	299
17	Dasatinib	—	299
18	Crizotinib	—	298
19	Emetine	—	298
20	cbd	—	298
21	Sertraline	—	1,000
22	Afatinib	—	297
23	Astemizole Antihistamine drug now withdrawn from	—	280
24	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
25	cannabidiol	—	296
26	Clotrimazole	—	296
27	Daunorubicin	—	298
28	Hexachlorophene	—	300
29	Meclizine	—	121
30	Sorafenib	—	300
31	Quercetin	—	300
32	vinpocetine	—	299
33	alsterpaullone	—	12
34	Domperidone	—	299
35	Yohimbine	—	299
36	Clonidine	—	299
37	Oxymetazoline	—	298
38	Norepinephrine Precursor of epinephrine that is secreted by	—	298
39	Phentolamine	—	300
40	Idazoxan	—	300
41	Epinephrine	—	299
42	Phenylephrine	—	299
43	Mianserin	—	299
44	Dexmedetomidine	—	299
45	Rilmenidine Oxazole derivative that acts as	—	300
46	Naphazoline	—	298
47	Piperoxan	—	167
48	Cabergoline	—	299
49	Dihydroergotamine	—	299
50	Guanfacine	—	294

About the Platelet Aggregation (Plug Formation) Pathway

The Platelet Aggregation (Plug Formation) pathway is catalogued in Reactome (ID: R-HSA-76009) and involves 14 genes. In the BiohacksAI corpus, 324 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA2A, ADRA2B, ADRA2C, CSK, GRB2.