What compounds affect the Sensory Perception pathway?

140 compounds in the BiohacksAI corpus have documented interactions with genes in the Sensory Perception pathway (Reactome ID: R-HSA-9709957). These compounds target 52 genes within this pathway.

What genes are in the Sensory Perception pathway?

The Sensory Perception pathway involves 52 genes. Key genes include: AKR1B10, AKR1C1, AKR1C3, AKR1C4, CACNA1D, CACNA2D2, CASK, CHURC1-FNTB, CNGA1, FNTA.

Sensory Perception

REACTOME PATHWAY

Reactome: R-HSA-970995752 genes140 compounds

The Sensory Perception pathway (Reactome ID: R-HSA-9709957) involves 52 genes and is affected by 140 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1B10 AKR1C1 AKR1C3 AKR1C4 CACNA1D CACNA2D2 CASK CHURC1-FNTB CNGA1 FNTA FNTB GRK4 GRM1 GRM4 HSD17B1 KCNMA1 KCNMB1 METAP1 MYO3A MYO3B OPN1LW OR51E2 PDE6A PNLIP RBP4 SCN2A SCN3A SCN9A TAS1R3 TAS2R1+22 more

Compounds Affecting Sensory Perception

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Lovastatin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	pterostilbene	—	299
5	Nisoldipine	—	297
6	Saxitoxin	—	300
7	Lacosamide	—	297
8	Quinidine	—	298
9	Veratridine	—	300
10	Kaempferols	—	300
11	Gliotoxin	—	300
12	Budesonide	—	1,000
13	Resveratrol	—	298
14	Carvedilol	—	296
15	Fluocinolone Acetonide	—	295
16	Latanoprost	—	299
17	Promethazine	—	121
18	Thioridazine	—	35
19	Thyroxine	—	994
20	Amoxapine	—	259
21	nafadotride	—	14
22	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
23	Nortriptyline	—	28
24	Perphenazine	—	297
25	Ritonavir	—	298
26	Thyroxine	—	300
27	Flunarizine Flunarizine is	—	299
28	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
29	Etidocaine	—	300
30	lidoflazine	—	278
31	Mianserin	—	299
32	Bupivacaine	—	300
33	Chlorpheniramine	—	298
34	Cinnarizine	—	299
35	Cyproheptadine	—	299
36	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
37	Dibucaine	—	299
38	dilazep	—	300
39	Hydroxyzine	—	298
40	Lidocaine	—	299
41	Nortriptyline	—	295
42	Phenobarbital	—	297
43	Phentolamine	—	300
44	Promethazine	—	296
45	protriptyline	—	296
46	Reserpine	—	297
47	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
48	egcg	—	300
49	Masoprocol	—	300
50	Genistein	—	300

About the Sensory Perception Pathway

The Sensory Perception pathway is catalogued in Reactome (ID: R-HSA-9709957) and involves 52 genes. In the BiohacksAI corpus, 140 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1B10, AKR1C1, AKR1C3, AKR1C4, CACNA1D.