TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Q: What compounds affect the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway?

279 compounds in the BiohacksAI corpus have documented interactions with genes in the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway (Reactome ID: R-HSA-975138). These compounds target 41 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97513841 genes279 compounds

The TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway (Reactome ID: R-HSA-975138) involves 41 genes and is affected by 279 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK CREB1 CUL1 DUSP3 FOS HMGB1 IKBKB IRAK1 IRAK4 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NFKB2 NFKBIA NOD1 NOD2+11 more

Compounds Affecting TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Quercetin	—	300
4	withaferin	—	300
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Dasatinib	—	299
8	Afatinib	—	297
9	Anisomycin	—	247
10	Crizotinib	—	298
11	Disulfiram	—	297
12	Axitinib	—	298
13	Resveratrol	—	298
14	Oxyphenbutazone	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	fisetin	—	78
17	Bortezomib	—	300
18	Kaempferols	—	300
19	Trifluridine	—	295
20	plumbagin [Supplementary Concept]	—	300
21	cycloheximide	—	300
22	Digitoxin	—	300
23	Digoxin	—	299
24	pd98059	—	7
25	egcg	—	300
26	Podophyllotoxin	—	14
27	alsterpaullone	—	12
28	chicoric acid	—	117
29	pictilisib	—	25
30	Hexachlorophene	—	300
31	Methylene Blue	—	200
32	Cladribine	—	297
33	ninhydrin	—	300
34	Camptothecin	—	300
35	Genistein	—	300
36	daph	—	2
37	Clotrimazole	—	296
38	Thioridazine	—	35
39	vinblastine sulfate	—	81
40	Nisoldipine	—	297
41	Nocodazole Nocodazole is	—	215
42	Sertraline	—	1,000
43	Adenosine Triphosphate	—	300
44	Salmeterol Xinafoate	—	227
45	Masoprocol	—	300
46	Rutin	—	300
47	Withania	—	500
48	tamarixetin	—	26
49	tyrphostin ag 1478	—	4
50	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Pathway

The TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway is catalogued in Reactome (ID: R-HSA-975138) and involves 41 genes. In the BiohacksAI corpus, 279 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, CREB1, CUL1, DUSP3.