What compounds target HTR2B?

BiohacksAI has identified 78 compounds that interact with HTR2B (5-hydroxytryptamine receptor 2B). Top compounds include: Mianserin, Methysergide, Yohimbine, Methylergonovine, Aripiprazole. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR2B (5-hydroxytryptamine receptor 2B)?

HTR2B is 5-hydroxytryptamine receptor 2B. It is a molecular target for 78 compounds documented in PubMed bioassay data. UniProt ID: P41595. NCBI Gene ID: 3357.

HTR2B

MOLECULAR TARGET

5-hydroxytryptamine receptor 2B

UniProt: P41595 NCBI Gene: 335778 compounds

HTR2B (5-hydroxytryptamine receptor 2B) is targeted by 78 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR2B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Mianserin	2.77	15
2	Methysergide	2.64	13
3	Yohimbine	2.48	11
4	Methylergonovine	2.30	9
5	Aripiprazole	2.20	8
6	Cabergoline	2.20	8
7	Quipazine	2.20	8
8	Buspirone	2.08	7
9	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	2.08	7
10	Metergoline	2.08	7
11	Pergolide	2.08	7
12	Trazodone	2.08	7
13	Quetiapine Fumarate	1.79	5
14	Fluoxetine	1.61	4
15	Bromocriptine	1.61	4
16	Dihydroergotamine	1.61	4
17	Ergotamine	1.61	4
18	Lisuride	1.61	4
19	Mescaline Hallucinogenic alkaloid isolated from	1.61	4
20	Amisulpride	1.39	3
21	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
22	Cyproheptadine	1.39	3
23	Guanfacine	1.39	3
24	Nortriptyline	1.39	3
25	Pindolol	1.39	3
26	Piribedil	1.39	3
27	Quinidine	1.39	3
28	Melatonin	1.10	2
29	Psilocybin	1.10	2
30	Amoxapine	1.10	2
31	Astemizole Antihistamine drug now withdrawn from	1.10	2
32	brl 15572	1.10	2
33	Carvedilol	1.10	2
34	Chlorhexidine	1.10	2
35	Crizotinib	1.10	2
36	Fluspirilene	1.10	2
37	Hydroxyzine	1.10	2
38	Loxapine	1.10	2
39	Metoclopramide	1.10	2
40	Nylidrin	1.10	2
41	Ondansetron	1.10	2
42	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.10	2
43	pirenperone	1.10	2
44	Promethazine	1.10	2
45	Propranolol	1.10	2
46	Sorafenib	1.10	2
47	Amlodipine	0.69	1
48	cbd	0.69	1
49	Phenformin	0.69	1
50	Sertraline	0.69	1

Showing top 50 of 78 compounds. Use the BiohacksAI search to explore all HTR2B modulators.

About HTR2B as a Drug Target

HTR2B (5-hydroxytryptamine receptor 2B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 78 compounds with documented HTR2B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR2B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.