What compounds affect the Signaling by NTRK1 (TRKA) pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NTRK1 (TRKA) pathway (Reactome ID: R-HSA-187037). These compounds target 35 genes within this pathway.

What genes are in the Signaling by NTRK1 (TRKA) pathway?

The Signaling by NTRK1 (TRKA) pathway involves 35 genes. Key genes include: BRAF, CDK5, CDK5R1, CREB1, DUSP3, EP300, F3, FOS, GRB2, ID4.

Signaling by NTRK1 (TRKA)

REACTOME PATHWAY

Reactome: R-HSA-18703735 genes100 compounds

The Signaling by NTRK1 (TRKA) pathway (Reactome ID: R-HSA-187037) involves 35 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF CDK5 CDK5R1 CREB1 DUSP3 EP300 F3 FOS GRB2 ID4 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAPK2 NTRK1 NTRK2 PIK3CB PIK3R1 PIK3R2 PPP2CA RPS6KA1 RPS6KA2 RPS6KA3+5 more

Compounds Affecting Signaling by NTRK1 (TRKA)

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Dasatinib	—	299
4	fisetin	—	78
5	Quercetin	—	300
6	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
7	withaferin	—	300
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	Afatinib	—	297
11	pictilisib	—	25
12	pd98059	—	7
13	trametinib	—	296
14	hydroxyfasudil [Supplementary Concept]	—	11
15	egcg	—	300
16	Anisomycin	—	247
17	Crizotinib	—	298
18	Axitinib	—	298
19	Vemurafenib	—	298
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	chrysin	—	300
22	plumbagin [Supplementary Concept]	—	300
23	tyrphostin ag 1478	—	4
24	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
25	Resveratrol	—	298
26	ly294002	—	11
27	Sirolimus	—	300
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	Dactinomycin	—	297
30	trequinsin hydrochloride	—	1
31	Masoprocol	—	300
32	indirubin	—	300
33	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
34	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
35	Celecoxib	—	295
36	Niclosamide	—	299
37	Wortmannin	—	300
38	alpelisib	—	227
39	Oleanolic Acid	—	300
40	cycloheximide	—	300
41	Disulfiram	—	297
42	Azacitidine	—	298
43	Azacitidine	—	300
44	Levalbuterol	—	1,000
45	Levalbuterol	—	297
46	Bortezomib	—	300
47	Clofarabine	—	298
48	Danazol	—	298
49	Emetine	—	298
50	Ethidium	—	300

About the Signaling by NTRK1 (TRKA) Pathway

The Signaling by NTRK1 (TRKA) pathway is catalogued in Reactome (ID: R-HSA-187037) and involves 35 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, CDK5, CDK5R1, CREB1, DUSP3.