What compounds affect the Signaling by Rho GTPases pathway?

414 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Rho GTPases pathway (Reactome ID: R-HSA-194315). These compounds target 93 genes within this pathway.

What genes are in the Signaling by Rho GTPases pathway?

The Signaling by Rho GTPases pathway involves 93 genes. Key genes include: ABL1, ABL2, AR, ARHGAP35, AURKB, BCR, BIRC5, BTK, BUB1B-PAK6, CCDC88A.

Signaling by Rho GTPases

REACTOME PATHWAY

Reactome: R-HSA-19431593 genes414 compounds

The Signaling by Rho GTPases pathway (Reactome ID: R-HSA-194315) involves 93 genes and is affected by 414 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 AR ARHGAP35 AURKB BCR BIRC5 BTK BUB1B-PAK6 CCDC88A CCT2 CDC37 CDC42 CDC42BPA CDC42BPB CFL1 CFTR CIT CSK CYBB EPHA2 GRB2 HSP90AA1 HSP90AB1 HSPE1 KDM1A KDM4C LCK LIMK1 LIMK2+63 more

Compounds Affecting Signaling by Rho GTPases

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Nocodazole Nocodazole is	—	215
3	Sorafenib	—	300
4	Colchicine	—	300
5	Crizotinib	—	298
6	vinblastine sulfate	—	81
7	Podophyllotoxin	—	14
8	Vincristine	—	299
9	Demecolcine	—	246
10	kenpaullone	—	8
11	Vorinostat	—	299
12	Noscapine	—	300
13	Maytansine	—	300
14	Quercetin	—	300
15	alsterpaullone	—	12
16	Axitinib	—	298
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	sp600125	—	117
19	Afatinib	—	297
20	tyrphostin ag 1478	—	4
21	hydroxyfasudil [Supplementary Concept]	—	11
22	Hexachlorophene	—	300
23	triolimus [Supplementary Concept]	—	33
24	celastrol	—	300
25	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
26	Clotrimazole	—	296
27	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
28	Wortmannin	—	300
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	cycloheximide	—	300
31	Disulfiram	—	297
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Methylene Blue	—	200
34	Masoprocol	—	300
35	egcg	—	300
36	Idarubicin	—	299
37	plumbagin [Supplementary Concept]	—	300
38	withaferin	—	300
39	Hydrocortisone	—	299
40	Hydrocortisone	—	298
41	Nisoldipine	—	297
42	Kaempferols	—	300
43	Genistein	—	300
44	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
45	Vitamin K 3	—	300
46	Oxyphenbutazone	—	300
47	Imatinib Mesylate	—	300
48	Niclosamide	—	299
49	rafoxanide	—	172
50	caffeic acid	—	300

About the Signaling by Rho GTPases Pathway

The Signaling by Rho GTPases pathway is catalogued in Reactome (ID: R-HSA-194315) and involves 93 genes. In the BiohacksAI corpus, 414 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, AR, ARHGAP35, AURKB.