What compounds affect the Co-inhibition by PD-1 pathway?

344 compounds in the BiohacksAI corpus have documented interactions with genes in the Co-inhibition by PD-1 pathway (Reactome ID: R-HSA-389948). These compounds target 78 genes within this pathway.

What genes are in the Co-inhibition by PD-1 pathway?

The Co-inhibition by PD-1 pathway involves 78 genes. Key genes include: ADRM1, AGO2, ASH2L, BRD4, CDK4, COPS5, CREBBP, CSK, CSNK2A1, CSNK2A2.

Co-inhibition by PD-1

REACTOME PATHWAY

Reactome: R-HSA-38994878 genes344 compounds

The Co-inhibition by PD-1 pathway (Reactome ID: R-HSA-389948) involves 78 genes and is affected by 344 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 ASH2L BRD4 CDK4 COPS5 CREBBP CSK CSNK2A1 CSNK2A2 CSNK2B CUL1 DPY30 EED EP300 EPAS1 EZH2 FOS GSK3B HIF1A JUN KMT2A LCK MYC NEK2 NFE2L2 NFKB1 NFKB2 PRKAA1 PRKAA2+48 more

Compounds Affecting Co-inhibition by PD-1

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Rotenone	—	300
6	Niclosamide	—	299
7	Kaempferols	—	300
8	Oleanolic Acid	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Antimycin	—	300
11	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
12	Ursolic Acid	—	300
13	egcg	—	300
14	Berberine	—	300
15	chrysin	—	300
16	ly294002	—	11
17	Adenosine Monophosphate Adenine nucleotide containing	—	300
18	Proguanil	—	299
19	Metformin	—	1,000
20	Resveratrol	—	298
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	sp600125	—	117
23	s adenosylhomocysteine	—	300
24	Podophyllotoxin	—	14
25	Rutin	—	300
26	Sorafenib	—	300
27	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
28	Colchicine	—	300
29	Hexachlorophene	—	300
30	Nocodazole Nocodazole is	—	215
31	Axitinib	—	298
32	ninhydrin	—	300
33	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
34	Clotrimazole	—	296
35	Disulfiram	—	297
36	Masoprocol	—	300
37	fisetin	—	78
38	Genistein	—	300
39	Methylene Blue	—	200
40	Ethoxyquin Antioxidant; also	—	180
41	vinblastine sulfate	—	81
42	Digoxin	—	299
43	DEAD-box RNA Helicases	—	169
44	Thioctic Acid	—	298
45	Oxyphenbutazone	—	300
46	Thioctic Acid	—	300
47	Nisoldipine	—	297
48	Budesonide	—	1,000
49	Phenoxybenzamine	—	21
50	Hydrocortisone	—	299

About the Co-inhibition by PD-1 Pathway

The Co-inhibition by PD-1 pathway is catalogued in Reactome (ID: R-HSA-389948) and involves 78 genes. In the BiohacksAI corpus, 344 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, ASH2L, BRD4, CDK4.