What compounds affect the G alpha (s) signalling events pathway?

399 compounds in the BiohacksAI corpus have documented interactions with genes in the G alpha (s) signalling events pathway (Reactome ID: R-HSA-418555). These compounds target 60 genes within this pathway.

What genes are in the G alpha (s) signalling events pathway?

The G alpha (s) signalling events pathway involves 60 genes. Key genes include: ADCY9, ADORA2B, ADRB1, ADRB2, ADRB3, ARRB1, AVPR2, CALCR, CRHR1, CYSLTR2.

G alpha (s) signalling events

REACTOME PATHWAY

Reactome: R-HSA-41855560 genes399 compounds

The G alpha (s) signalling events pathway (Reactome ID: R-HSA-418555) involves 60 genes and is affected by 399 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADORA2B ADRB1 ADRB2 ADRB3 ARRB1 AVPR2 CALCR CRHR1 CYSLTR2 DRD1 DRD5 GHRHR GLP1R GLP2R GNAI1 GNAS GPBAR1 GPER1 GPR32 GPR84 GRK2 GRK6 HRH2 HTR4 HTR6 HTR7 MC1R MC2R MC3R+30 more

Compounds Affecting G alpha (s) signalling events

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Bromocriptine	—	299
3	Carvedilol	—	296
4	Dihydroergotamine	—	299
5	Astemizole Antihistamine drug now withdrawn from	—	280
6	Clotrimazole	—	296
7	Papaverine	—	299
8	Metergoline	—	144
9	Lisuride	—	299
10	Amoxapine	—	259
11	Chlorhexidine	—	299
12	Pergolide	—	299
13	Norepinephrine Precursor of epinephrine that is secreted by	—	298
14	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
15	Hexachlorophene	—	300
16	Loxapine	—	225
17	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
18	Nortriptyline	—	295
19	Perphenazine	—	297
20	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
21	Levalbuterol	—	1,000
22	Levalbuterol	—	297
23	Disulfiram	—	297
24	Mianserin	—	299
25	Epinephrine	—	299
26	Yohimbine	—	299
27	Fluoxetine	—	1,000
28	Calcimycin	—	216
29	Cyproheptadine	—	299
30	Phenylephrine	—	299
31	vinpocetine	—	299
32	Alprostadil	—	297
33	Cilostazol	—	297
34	Enoximone	—	300
35	Nicardipine	—	94
36	Tetrahydropapaveroline	—	139
37	Troglitazone	—	299
38	Fluspirilene	—	74
39	Dihydroergotamine	—	9
40	Methylene Blue	—	200
41	Dinoprostone	—	296
42	Quetiapine Fumarate	—	994
43	Sertraline	—	1,000
44	Maprotiline	—	299
45	Methysergide	—	300
46	Thioridazine	—	35
47	Cyclic AMP	—	300
48	Cyclic AMP	—	300
49	Domperidone	—	299
50	Niclosamide	—	299

About the G alpha (s) signalling events Pathway

The G alpha (s) signalling events pathway is catalogued in Reactome (ID: R-HSA-418555) and involves 60 genes. In the BiohacksAI corpus, 399 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADORA2B, ADRB1, ADRB2, ADRB3.