What compounds affect the G alpha (i) signalling events pathway?

474 compounds in the BiohacksAI corpus have documented interactions with genes in the G alpha (i) signalling events pathway (Reactome ID: R-HSA-418594). These compounds target 132 genes within this pathway.

What genes are in the G alpha (i) signalling events pathway?

The G alpha (i) signalling events pathway involves 132 genes. Key genes include: ADCY9, ADORA3, ADRA2A, ADRA2B, ADRA2C, AGTR2, APLNR, APP, BDKRB1, BDKRB2.

G alpha (i) signalling events

REACTOME PATHWAY

Reactome: R-HSA-418594132 genes474 compounds

The G alpha (i) signalling events pathway (Reactome ID: R-HSA-418594) involves 132 genes and is affected by 474 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADORA3 ADRA2A ADRA2B ADRA2C AGTR2 APLNR APP BDKRB1 BDKRB2 C5 CAMK2B CAMK2D CAMKK1 CAMKK2 CASR CCR4 CCR6 CDK5 CHRM2 CHRM4 CNR1 CNR2 CREB1 CX3CR1 CXCL8 CXCR1 CXCR6 DRD3 DRD4+102 more

Compounds Affecting G alpha (i) signalling events

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Metergoline	—	144
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Fluspirilene	—	74
5	Disulfiram	—	297
6	Perphenazine	—	297
7	cbd	—	298
8	cannabidiol	—	296
9	Aripiprazole	—	298
10	Quercetin	—	300
11	Quetiapine Fumarate	—	994
12	Amoxapine	—	259
13	Dihydroergotamine	—	9
14	Chlorhexidine	—	299
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Bromocriptine	—	299
17	Mianserin	—	299
18	Loxapine	—	225
19	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
20	Carvedilol	—	296
21	vinpocetine	—	299
22	Digoxin	—	299
23	Somatostatin	—	300
24	Calcimycin	—	216
25	Pramipexole	—	297
26	Lisuride	—	299
27	Yohimbine	—	299
28	Promethazine	—	296
29	Dequalinium	—	136
30	Dihydroergotamine	—	299
31	Hexachlorophene	—	300
32	Meclizine	—	121
33	Methysergide	—	300
34	Nortriptyline	—	295
35	hydroxyfasudil [Supplementary Concept]	—	11
36	Niclosamide	—	299
37	Crizotinib	—	298
38	alsterpaullone	—	12
39	Clotrimazole	—	296
40	Aurintricarboxylic Acid	—	184
41	Adenosine Triphosphate	—	300
42	Papaverine	—	299
43	Camptothecin	—	300
44	Glutamic Acid	—	297
45	Glutamic Acid	—	300
46	Pergolide	—	299
47	Cabergoline	—	299
48	Metoclopramide	—	297
49	Piribedil	—	300
50	Buspirone	—	299

About the G alpha (i) signalling events Pathway

The G alpha (i) signalling events pathway is catalogued in Reactome (ID: R-HSA-418594) and involves 132 genes. In the BiohacksAI corpus, 474 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADORA3, ADRA2A, ADRA2B, ADRA2C.