What compounds affect the Regulation of insulin secretion pathway?

221 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of insulin secretion pathway (Reactome ID: R-HSA-422356). These compounds target 22 genes within this pathway.

What genes are in the Regulation of insulin secretion pathway?

The Regulation of insulin secretion pathway involves 22 genes. Key genes include: ABCC8, ADRA2A, ADRA2C, CACNA1C, CACNA1D, CACNA2D2, CHRM3, FFAR1, GLP1R, GNA15.

Regulation of insulin secretion

REACTOME PATHWAY

Reactome: R-HSA-42235622 genes221 compounds

The Regulation of insulin secretion pathway (Reactome ID: R-HSA-422356) involves 22 genes and is affected by 221 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC8 ADRA2A ADRA2C CACNA1C CACNA1D CACNA2D2 CHRM3 FFAR1 GLP1R GNA15 GNAI1 GNAS INS KCNB1 PLCB3 PRKACA PRKACB PRKACG RAPGEF3 RAPGEF4 SLC2A1 SLC2A2

Compounds Affecting Regulation of insulin secretion

#	Compound	Targets Hit	Studies
1	Astemizole Antihistamine drug now withdrawn from	—	280
2	Fluoxetine	—	1,000
3	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
4	Amlodipine	—	1,000
5	hydroxyfasudil [Supplementary Concept]	—	11
6	Perphenazine	—	297
7	Fluspirilene	—	74
8	Idarubicin	—	299
9	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
10	Yohimbine	—	299
11	Mianserin	—	299
12	Aripiprazole	—	298
13	Bromocriptine	—	299
14	Quetiapine Fumarate	—	994
15	Dihydroergotamine	—	9
16	Emetine	—	298
17	Loxapine	—	225
18	Metergoline	—	144
19	Promethazine	—	296
20	Amoxapine	—	259
21	Chlorhexidine	—	299
22	Maprotiline	—	299
23	Nortriptyline	—	295
24	Duloxetine Hydrochloride	—	993
25	Clotrimazole	—	296
26	Nitrendipine	—	299
27	Arachidonic Acid	—	245
28	Aurintricarboxylic Acid	—	184
29	Daunorubicin	—	298
30	Clonidine	—	299
31	Oxymetazoline	—	298
32	Norepinephrine Precursor of epinephrine that is secreted by	—	298
33	Phentolamine	—	300
34	Idazoxan	—	300
35	Epinephrine	—	299
36	Phenylephrine	—	299
37	Dexmedetomidine	—	299
38	Rilmenidine Oxazole derivative that acts as	—	300
39	Naphazoline	—	298
40	Piperoxan	—	167
41	Cabergoline	—	299
42	Dihydroergotamine	—	299
43	Guanfacine	—	294
44	Pergolide	—	299
45	Tolazoline	—	300
46	Carvedilol	—	296
47	Tamsulosin	—	298
48	Lisuride	—	299
49	Guanabenz	—	298
50	Metoclopramide	—	297

About the Regulation of insulin secretion Pathway

The Regulation of insulin secretion pathway is catalogued in Reactome (ID: R-HSA-422356) and involves 22 genes. In the BiohacksAI corpus, 221 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC8, ADRA2A, ADRA2C, CACNA1C, CACNA1D.