What compounds affect the Mitotic G1 phase and G1/S transition pathway?

149 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitotic G1 phase and G1/S transition pathway (Reactome ID: R-HSA-453279). These compounds target 60 genes within this pathway.

What genes are in the Mitotic G1 phase and G1/S transition pathway?

The Mitotic G1 phase and G1/S transition pathway involves 60 genes. Key genes include: ABL1, ADRM1, AKT3, CCNA1, CCNB1, CCNE2, CDC25A, CDC7, CDK1, CDK2.

Mitotic G1 phase and G1/S transition

REACTOME PATHWAY

Reactome: R-HSA-45327960 genes149 compounds

The Mitotic G1 phase and G1/S transition pathway (Reactome ID: R-HSA-453279) involves 60 genes and is affected by 149 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AKT3 CCNA1 CCNB1 CCNE2 CDC25A CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CUL1 DHFR GMNN HDAC1 JAK2 LYN MYC PCNA PPP2CA PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1+30 more

Compounds Affecting Mitotic G1 phase and G1/S transition

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Sorafenib	—	300
6	Dasatinib	—	299
7	Quercetin	—	300
8	indirubin	—	300
9	sp600125	—	117
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	chrysin	—	300
12	fisetin	—	78
13	Crizotinib	—	298
14	tyrphostin ag 1478	—	4
15	Genistein	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Disulfiram	—	297
19	Rotenone	—	300
20	2-Methoxyestradiol	—	300
21	Nocodazole Nocodazole is	—	215
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Podophyllotoxin	—	14
24	Vorinostat	—	299
25	Digitoxin	—	300
26	Niclosamide	—	299
27	Calcitriol	—	300
28	Clotrimazole	—	296
29	triolimus [Supplementary Concept]	—	33
30	Vidarabine	—	299
31	Afatinib	—	297
32	Adenosine Triphosphate	—	300
33	Camptothecin	—	300
34	Cytarabine	—	297
35	Trifluridine	—	295
36	Daunorubicin	—	298
37	egcg	—	300
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	pictilisib	—	25
40	Pemetrexed	—	299
41	Methotrexate	—	289
42	Thymidine Monophosphate 5-Thymidylic acid.	—	202
43	hydroxyfasudil [Supplementary Concept]	—	11
44	Colchicine	—	300
45	Metergoline	—	144
46	triflupromazine hydrochloride	—	12
47	Calcimycin	—	216
48	Doxazosin	—	24
49	Ethinyl Estradiol	—	300
50	Hexachlorophene	—	300

About the Mitotic G1 phase and G1/S transition Pathway

The Mitotic G1 phase and G1/S transition pathway is catalogued in Reactome (ID: R-HSA-453279) and involves 60 genes. In the BiohacksAI corpus, 149 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AKT3, CCNA1, CCNB1.