What genes are in the Interleukin-4 and Interleukin-13 signaling pathway?

The Interleukin-4 and Interleukin-13 signaling pathway involves 36 genes. Key genes include: ALOX15, ALOX5, BCL2L1, BIRC5, CCL2, CXCL8, F13A1, FOS, FOXO3, HIF1A.

Interleukin-4 and Interleukin-13 signaling

Q: What compounds affect the Interleukin-4 and Interleukin-13 signaling pathway?

364 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-4 and Interleukin-13 signaling pathway (Reactome ID: R-HSA-6785807). These compounds target 36 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-678580736 genes364 compounds

The Interleukin-4 and Interleukin-13 signaling pathway (Reactome ID: R-HSA-6785807) involves 36 genes and is affected by 364 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX5 BCL2L1 BIRC5 CCL2 CXCL8 F13A1 FOS FOXO3 HIF1A HSP90AA1 HSP90B1 HSPA8 ICAM1 IL1B IL6 ITGB2 JAK2 JAK3 MAOA MCL1 MUC1 MYC NOS2 OPRD1 OPRM1 PIK3R1 PIM1 POU2F1 PTGS2+6 more

Compounds Affecting Interleukin-4 and Interleukin-13 signaling

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Quercetin	—	300
3	Hexachlorophene	—	300
4	sp600125	—	117
5	Masoprocol	—	300
6	Methylene Blue	—	200
7	Resveratrol	—	298
8	Digoxin	—	299
9	Celecoxib	—	295
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	Niclosamide	—	299
13	Camptothecin	—	300
14	cycloheximide	—	300
15	vinblastine sulfate	—	81
16	Harmaline	—	300
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	alsterpaullone	—	12
20	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
21	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Ethidium	—	300
24	Cladribine	—	297
25	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
26	Methotrexate	—	289
27	Disulfiram	—	297
28	Vitamin K 3	—	300
29	Axitinib	—	298
30	Clotrimazole	—	296
31	chrysin	—	300
32	celastrol	—	300
33	Nisoldipine	—	297
34	triolimus [Supplementary Concept]	—	33
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Colchicine	—	300
37	monorden	—	8
38	Phenylbutazone	—	300
39	Tripterygium	—	300
40	tyrphostin 9	—	2
41	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
42	streptonigrin	—	299
43	Wortmannin	—	300
44	Indomethacin	—	297
45	cbd	—	298
46	Calcitriol	—	300
47	cannabidiol	—	296
48	Sorafenib	—	300
49	Fentanyl	—	300
50	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300

About the Interleukin-4 and Interleukin-13 signaling Pathway

The Interleukin-4 and Interleukin-13 signaling pathway is catalogued in Reactome (ID: R-HSA-6785807) and involves 36 genes. In the BiohacksAI corpus, 364 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX5, BCL2L1, BIRC5, CCL2.