SARS-CoV-2 activates/modulates innate and adaptive immune responses

Q: What compounds affect the SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway?

120 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway (Reactome ID: R-HSA-9705671). These compounds target 22 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-970567122 genes120 compounds

The SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway (Reactome ID: R-HSA-9705671) involves 22 genes and is affected by 120 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK CREBBP HLA-A HLA-B HSP90AA1 HSP90AB1 IFNB1 IKBKB IKBKE IRAK1 MAP3K7 NLRP3 NOD1 NOD2 PIK3C3 PTPN6 RIPK2 STAT1 TBK1 TLR2 TYK2 UBE2N

Compounds Affecting SARS-CoV-2 activates/modulates innate and adaptive immune responses

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	cycloheximide	—	300
3	celastrol	—	300
4	Disulfiram	—	297
5	Sorafenib	—	300
6	Camptothecin	—	300
7	Ouabain	—	300
8	Idarubicin	—	299
9	Calcimycin	—	216
10	Digitoxin	—	300
11	Digoxin	—	299
12	triolimus [Supplementary Concept]	—	33
13	Hexachlorophene	—	300
14	Axitinib	—	298
15	Bortezomib	—	300
16	Tripterygium	—	300
17	Sertraline	—	1,000
18	Afatinib	—	297
19	sp600125	—	117
20	Calcitriol	—	300
21	Anisomycin	—	247
22	withaferin	—	300
23	Emetine	—	298
24	Proscillaridin	—	219
25	Dactinomycin	—	297
26	Daunorubicin	—	298
27	Epirubicin	—	300
28	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
29	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
30	Azacitidine	—	298
31	Azacitidine	—	300
32	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
33	kenpaullone	—	8
34	cbd	—	298
35	cannabidiol	—	296
36	Deslanoside Deacetyllanatoside C.	—	89
37	Feprazone	—	63
38	Leflunomide	—	297
39	Thapsigargin	—	300
40	Genistein	—	300
41	Nitrendipine	—	299
42	Phenylbutazone	—	300
43	Methylene Blue	—	200
44	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
45	monorden	—	8
46	gedunin	—	54
47	Novobiocin	—	300
48	caffeic acid	—	300
49	Masoprocol	—	300
50	Tetracycline	—	300

About the SARS-CoV-2 activates/modulates innate and adaptive immune responses Pathway

The SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway is catalogued in Reactome (ID: R-HSA-9705671) and involves 22 genes. In the BiohacksAI corpus, 120 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, CREBBP, HLA-A, HLA-B, HSP90AA1.