What compounds affect the SARS-CoV-2-host interactions pathway?

131 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-2-host interactions pathway (Reactome ID: R-HSA-9705683). These compounds target 30 genes within this pathway.

What genes are in the SARS-CoV-2-host interactions pathway?

The SARS-CoV-2-host interactions pathway involves 30 genes. Key genes include: AKT3, CHUK, CREBBP, HLA-A, HLA-B, HSP90AA1, HSP90AB1, IFNB1, IKBKB, IKBKE.

SARS-CoV-2-host interactions

REACTOME PATHWAY

Reactome: R-HSA-970568330 genes131 compounds

The SARS-CoV-2-host interactions pathway (Reactome ID: R-HSA-9705683) involves 30 genes and is affected by 131 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CHUK CREBBP HLA-A HLA-B HSP90AA1 HSP90AB1 IFNB1 IKBKB IKBKE IRAK1 MAP1LC3B MAP3K7 NLRP3 NOD1 NOD2 PDPK1 PIK3C3 PTPN6 RIPK2 RPSA SMN1 SMN2 STAT1 TBK1 TLR2 TYK2 UBE2N YWHAB YWHAG

Compounds Affecting SARS-CoV-2-host interactions

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	cycloheximide	—	300
3	celastrol	—	300
4	Disulfiram	—	297
5	Idarubicin	—	299
6	Sorafenib	—	300
7	Camptothecin	—	300
8	Ouabain	—	300
9	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
10	Calcimycin	—	216
11	kenpaullone	—	8
12	Digitoxin	—	300
13	Digoxin	—	299
14	triolimus [Supplementary Concept]	—	33
15	sp600125	—	117
16	Hexachlorophene	—	300
17	Axitinib	—	298
18	Bortezomib	—	300
19	Tripterygium	—	300
20	Leflunomide	—	297
21	Genistein	—	300
22	Sertraline	—	1,000
23	Afatinib	—	297
24	Novobiocin	—	300
25	Masoprocol	—	300
26	Quercetin	—	300
27	Calcitriol	—	300
28	piceatannol	—	300
29	Niclosamide	—	299
30	Anisomycin	—	247
31	alsterpaullone	—	12
32	withaferin	—	300
33	Emetine	—	298
34	Proscillaridin	—	219
35	Dactinomycin	—	297
36	Daunorubicin	—	298
37	Epirubicin	—	300
38	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
39	Azacitidine	—	298
40	Azacitidine	—	300
41	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
42	cbd	—	298
43	cannabidiol	—	296
44	Deslanoside Deacetyllanatoside C.	—	89
45	Feprazone	—	63
46	Thapsigargin	—	300
47	Nitrendipine	—	299
48	Phenylbutazone	—	300
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
50	Methylene Blue	—	200

About the SARS-CoV-2-host interactions Pathway

The SARS-CoV-2-host interactions pathway is catalogued in Reactome (ID: R-HSA-9705683) and involves 30 genes. In the BiohacksAI corpus, 131 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CHUK, CREBBP, HLA-A, HLA-B.