What genes are in the Cellular responses to mechanical stimuli pathway?

The Cellular responses to mechanical stimuli pathway involves 39 genes. Key genes include: ABL1, ADCY9, ANXA2, CACNA1H, CACNA2D1, CHUK, FLT4, FYN, GNAS, IKBKB.

Cellular responses to mechanical stimuli

Q: What compounds affect the Cellular responses to mechanical stimuli pathway?

199 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular responses to mechanical stimuli pathway (Reactome ID: R-HSA-9855142). These compounds target 39 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-985514239 genes199 compounds

The Cellular responses to mechanical stimuli pathway (Reactome ID: R-HSA-9855142) involves 39 genes and is affected by 199 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADCY9 ANXA2 CACNA1H CACNA2D1 CHUK FLT4 FYN GNAS IKBKB IKBKE ITGAV ITGB3 KDR MAPKAP1 MLST8 MMP14 MTOR NFKB1 NFKBIA NOS3 P2RX7 P2RY2 PANX1 PDE4D PDPK1 PIK3CB PIK3CD PIK3R2 PKN2+9 more

Compounds Affecting Cellular responses to mechanical stimuli

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Resveratrol	—	298
3	ly294002	—	11
4	Sirolimus	—	300
5	torin 1	—	10
6	Ku 0063794 [Supplementary Concept]	—	7
7	alpelisib	—	227
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	Quercetin	—	300
11	egcg	—	300
12	pictilisib	—	25
13	Adenosine Triphosphate	—	300
14	chicoric acid	—	117
15	Sorafenib	—	300
16	Axitinib	—	298
17	Dasatinib	—	299
18	sp600125	—	117
19	hydroxyfasudil [Supplementary Concept]	—	11
20	Podophyllotoxin	—	14
21	Genistein	—	300
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	tyrphostin ag 1478	—	4
25	Wortmannin	—	300
26	Ursolic Acid	—	300
27	Rotenone	—	300
28	Camptothecin	—	300
29	Thapsigargin	—	300
30	celastrol	—	300
31	Emetine	—	298
32	Nocodazole Nocodazole is	—	215
33	tyrphostin 9	—	2
34	Bortezomib	—	300
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Kaempferols	—	300
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	Rutin	—	300
39	Withania	—	500
40	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
41	streptonigrin	—	299
42	tamarixetin	—	26
43	Trifluridine	—	295
44	tyrphostin 1	—	1
45	withaferin	—	300
46	Everolimus	—	297
47	Calcimycin	—	216
48	Niclosamide	—	299
49	triolimus [Supplementary Concept]	—	33
50	Oleanolic Acid	—	300

About the Cellular responses to mechanical stimuli Pathway

The Cellular responses to mechanical stimuli pathway is catalogued in Reactome (ID: R-HSA-9855142) and involves 39 genes. In the BiohacksAI corpus, 199 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADCY9, ANXA2, CACNA1H, CACNA2D1.