What compounds affect the Regulation of PD-L1(CD274) transcription pathway?

316 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PD-L1(CD274) transcription pathway (Reactome ID: R-HSA-9909649). These compounds target 24 genes within this pathway.

What genes are in the Regulation of PD-L1(CD274) transcription pathway?

The Regulation of PD-L1(CD274) transcription pathway involves 24 genes. Key genes include: ASH2L, BRD4, CREBBP, DPY30, EED, EP300, EPAS1, EZH2, FOS, HIF1A.

Regulation of PD-L1(CD274) transcription

REACTOME PATHWAY

Reactome: R-HSA-990964924 genes316 compounds

The Regulation of PD-L1(CD274) transcription pathway (Reactome ID: R-HSA-9909649) involves 24 genes and is affected by 316 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L BRD4 CREBBP DPY30 EED EP300 EPAS1 EZH2 FOS HIF1A JUN KMT2A MYC NFE2L2 NFKB1 NFKB2 RBBP5 RELA STAT1 STAT3 TCF7L2 TEAD4 WDR5 YAP1

Compounds Affecting Regulation of PD-L1(CD274) transcription

#	Compound	Targets Hit	Studies
1	Resveratrol	—	298
2	Quercetin	—	300
3	Bortezomib	—	300
4	s adenosylhomocysteine	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Podophyllotoxin	—	14
7	Kaempferols	—	300
8	egcg	—	300
9	Colchicine	—	300
10	Nocodazole Nocodazole is	—	215
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
13	Rotenone	—	300
14	Methylene Blue	—	200
15	Ethoxyquin Antioxidant; also	—	180
16	Niclosamide	—	299
17	vinblastine sulfate	—	81
18	Digoxin	—	299
19	Hexachlorophene	—	300
20	Oxyphenbutazone	—	300
21	Nisoldipine	—	297
22	Budesonide	—	1,000
23	Clotrimazole	—	296
24	Disulfiram	—	297
25	Masoprocol	—	300
26	Phenoxybenzamine	—	21
27	Hydrocortisone	—	299
28	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
29	Hydrocortisone	—	298
30	Lovastatin	—	300
31	ly294002	—	11
32	Trifluridine	—	295
33	Emetine	—	298
34	cycloheximide	—	300
35	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
36	Tubercidin	—	300
37	Rutin	—	300
38	Withania	—	500
39	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
40	tamarixetin	—	26
41	withaferin	—	300
42	Azacitidine	—	298
43	Azacitidine	—	300
44	Genistein	—	300
45	Mestranol	—	300
46	chrysin	—	300
47	Vitamin K 3	—	300
48	Ouabain	—	300
49	Toxaphene	—	299
50	DEAD-box RNA Helicases	—	169

About the Regulation of PD-L1(CD274) transcription Pathway

The Regulation of PD-L1(CD274) transcription pathway is catalogued in Reactome (ID: R-HSA-9909649) and involves 24 genes. In the BiohacksAI corpus, 316 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, BRD4, CREBBP, DPY30, EED.