What compounds affect the Integration of energy metabolism pathway?

247 compounds in the BiohacksAI corpus have documented interactions with genes in the Integration of energy metabolism pathway (Reactome ID: R-HSA-163685). These compounds target 29 genes within this pathway.

What genes are in the Integration of energy metabolism pathway?

The Integration of energy metabolism pathway involves 29 genes. Key genes include: ABCC8, ADCY9, ADRA2A, ADRA2C, CACNA1C, CACNA1D, CACNA2D2, CHRM3, FASN, FFAR1.

Integration of energy metabolism

REACTOME PATHWAY

Reactome: R-HSA-16368529 genes247 compounds

The Integration of energy metabolism pathway (Reactome ID: R-HSA-163685) involves 29 genes and is affected by 247 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC8 ADCY9 ADRA2A ADRA2C CACNA1C CACNA1D CACNA2D2 CHRM3 FASN FFAR1 GLP1R GNA15 GNAI1 GNAS INS KCNB1 PKLR PLCB3 PPP2CA PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 RAPGEF3 RAPGEF4 SLC2A1 SLC2A2

Compounds Affecting Integration of energy metabolism

#	Compound	Targets Hit	Studies
1	Astemizole Antihistamine drug now withdrawn from	—	280
2	Niclosamide	—	299
3	Fluoxetine	—	1,000
4	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
5	Amlodipine	—	1,000
6	hydroxyfasudil [Supplementary Concept]	—	11
7	Perphenazine	—	297
8	Fluspirilene	—	74
9	Idarubicin	—	299
10	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
11	Antimycin	—	300
12	Aurintricarboxylic Acid	—	184
13	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
14	Yohimbine	—	299
15	Mianserin	—	299
16	Aripiprazole	—	298
17	Bromocriptine	—	299
18	Quetiapine Fumarate	—	994
19	Dihydroergotamine	—	9
20	Emetine	—	298
21	Loxapine	—	225
22	Metergoline	—	144
23	Promethazine	—	296
24	Rutin	—	300
25	Amoxapine	—	259
26	Chlorhexidine	—	299
27	Maprotiline	—	299
28	Nortriptyline	—	295
29	Duloxetine Hydrochloride	—	993
30	Clotrimazole	—	296
31	Nitrendipine	—	299
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	Hexachlorophene	—	300
34	Arachidonic Acid	—	245
35	Daunorubicin	—	298
36	Adenosine Monophosphate Adenine nucleotide containing	—	300
37	Proguanil	—	299
38	Berberine	—	300
39	Ursolic Acid	—	300
40	Oleanolic Acid	—	300
41	Rotenone	—	300
42	Metformin	—	1,000
43	Clonidine	—	299
44	Oxymetazoline	—	298
45	Norepinephrine Precursor of epinephrine that is secreted by	—	298
46	Phentolamine	—	300
47	Idazoxan	—	300
48	Epinephrine	—	299
49	Phenylephrine	—	299
50	Dexmedetomidine	—	299

About the Integration of energy metabolism Pathway

The Integration of energy metabolism pathway is catalogued in Reactome (ID: R-HSA-163685) and involves 29 genes. In the BiohacksAI corpus, 247 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC8, ADCY9, ADRA2A, ADRA2C, CACNA1C.