What compounds affect the Signal Transduction pathway?

1070 compounds in the BiohacksAI corpus have documented interactions with genes in the Signal Transduction pathway (Reactome ID: R-HSA-162582). These compounds target 656 genes within this pathway.

What genes are in the Signal Transduction pathway?

The Signal Transduction pathway involves 656 genes. Key genes include: ABL1, ABL2, ACVR1B, ACVR2A, ACVR2B, ACVRL1, ADAM10, ADAM17, ADCY9, ADORA2B.

Signal Transduction

REACTOME PATHWAY

Reactome: R-HSA-162582656 genes1070 compounds

The Signal Transduction pathway (Reactome ID: R-HSA-162582) involves 656 genes and is affected by 1070 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 ACVR1B ACVR2A ACVR2B ACVRL1 ADAM10 ADAM17 ADCY9 ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRM1 AGO2 AGTR1 AGTR2 AKR1C3 AKT3 ALDH1A1 ALK APH1A APH1B+626 more

Compounds Affecting Signal Transduction

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Crizotinib	—	298
3	Dasatinib	—	299
4	Quercetin	—	300
5	sp600125	—	117
6	Bortezomib	—	300
7	Axitinib	—	298
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Hexachlorophene	—	300
11	Disulfiram	—	297
12	Aripiprazole	—	298
13	Daunorubicin	—	298
14	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
15	Clotrimazole	—	296
16	Perphenazine	—	297
17	alsterpaullone	—	12
18	Chlorhexidine	—	299
19	Fluspirilene	—	74
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	kenpaullone	—	8
22	chrysin	—	300
23	Amoxapine	—	259
24	Niclosamide	—	299
25	Nocodazole Nocodazole is	—	215
26	Metergoline	—	144
27	vinblastine sulfate	—	81
28	Podophyllotoxin	—	14
29	egcg	—	300
30	Methylene Blue	—	200
31	Kaempferols	—	300
32	Fluoxetine	—	1,000
33	Vorinostat	—	299
34	Colchicine	—	300
35	Celecoxib	—	295
36	Ursolic Acid	—	300
37	pictilisib	—	25
38	Carvedilol	—	296
39	cycloheximide	—	300
40	Ethidium	—	300
41	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
42	Rotenone	—	300
43	Cyproheptadine	—	299
44	Mianserin	—	299
45	Loratadine	—	296
46	Maprotiline	—	299
47	Thioridazine	—	35
48	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
49	candesartan cilexetil [Supplementary Concept]	—	300
50	Masoprocol	—	300

About the Signal Transduction Pathway

The Signal Transduction pathway is catalogued in Reactome (ID: R-HSA-162582) and involves 656 genes. In the BiohacksAI corpus, 1070 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, ACVR1B, ACVR2A, ACVR2B.