What compounds affect the Serotonin receptors pathway?

193 compounds in the BiohacksAI corpus have documented interactions with genes in the Serotonin receptors pathway (Reactome ID: R-HSA-390666). These compounds target 8 genes within this pathway.

What genes are in the Serotonin receptors pathway?

The Serotonin receptors pathway involves 8 genes. Key genes include: HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR6, HTR7.

Serotonin receptors

REACTOME PATHWAY

Reactome: R-HSA-3906668 genes193 compounds

The Serotonin receptors pathway (Reactome ID: R-HSA-390666) involves 8 genes and is affected by 193 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HTR1A HTR1E HTR2A HTR2B HTR2C HTR4 HTR6 HTR7

Compounds Affecting Serotonin receptors

#	Compound	Targets Hit	Studies
1	Mescaline Hallucinogenic alkaloid isolated from	—	300
2	Metergoline	—	144
3	Mianserin	—	299
4	Quetiapine Fumarate	—	994
5	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
6	Cyproheptadine	—	299
7	Dihydroergotamine	—	299
8	Methysergide	—	300
9	Pergolide	—	299
10	Ergotamine	—	299
11	Lisuride	—	299
12	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
13	Nortriptyline	—	295
14	Aripiprazole	—	298
15	Quipazine	—	300
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Sumatriptan	—	298
18	Bufotenin	—	93
19	Amoxapine	—	259
20	Perphenazine	—	297
21	Yohimbine	—	299
22	Loxapine	—	225
23	brl 15572	—	2
24	Bromocriptine	—	299
25	Dihydroergotamine	—	9
26	Buspirone	—	299
27	Methylergonovine	—	193
28	Fluspirilene	—	74
29	Fluoxetine	—	1,000
30	pirenperone	—	22
31	Carvedilol	—	296
32	Chlorhexidine	—	299
33	Cabergoline	—	299
34	Oxymetazoline	—	298
35	Hydroxyzine	—	298
36	Promethazine	—	296
37	Pindolol	—	299
38	Trazodone	—	297
39	Duloxetine Hydrochloride	—	993
40	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
41	Ondansetron	—	299
42	Vortioxetine	—	294
43	Sorafenib	—	300
44	Psilocybin	—	300
45	Melatonin	—	297
46	Domperidone	—	299
47	Maprotiline	—	299
48	Amisulpride	—	298
49	Troglitazone	—	299
50	Propranolol	—	300

About the Serotonin receptors Pathway

The Serotonin receptors pathway is catalogued in Reactome (ID: R-HSA-390666) and involves 8 genes. In the BiohacksAI corpus, 193 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HTR1A, HTR1E, HTR2A, HTR2B, HTR2C.