What compounds affect the GPCR downstream signalling pathway?

725 compounds in the BiohacksAI corpus have documented interactions with genes in the GPCR downstream signalling pathway (Reactome ID: R-HSA-388396). These compounds target 245 genes within this pathway.

What genes are in the GPCR downstream signalling pathway?

The GPCR downstream signalling pathway involves 245 genes. Key genes include: ADCY9, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1.

GPCR downstream signalling

REACTOME PATHWAY

Reactome: R-HSA-388396245 genes725 compounds

The GPCR downstream signalling pathway (Reactome ID: R-HSA-388396) involves 245 genes and is affected by 725 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 AGTR2 AKT3 APLNR APP ARRB1 AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BTK C5 CALCR CAMK2B CAMK2D CAMKK1 CAMKK2+215 more

Compounds Affecting GPCR downstream signalling

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Aripiprazole	—	298
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Metergoline	—	144
5	Carvedilol	—	296
6	Fluspirilene	—	74
7	Amoxapine	—	259
8	Perphenazine	—	297
9	Chlorhexidine	—	299
10	Loxapine	—	225
11	Quetiapine Fumarate	—	994
12	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
13	Mianserin	—	299
14	Cyproheptadine	—	299
15	Dihydroergotamine	—	299
16	Fluoxetine	—	1,000
17	Nortriptyline	—	295
18	Dihydroergotamine	—	9
19	Pergolide	—	299
20	Bromocriptine	—	299
21	Lisuride	—	299
22	Maprotiline	—	299
23	Clotrimazole	—	296
24	Calcimycin	—	216
25	Hexachlorophene	—	300
26	Disulfiram	—	297
27	Yohimbine	—	299
28	Promethazine	—	296
29	Hydroxyzine	—	298
30	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
31	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
32	Methysergide	—	300
33	Thioridazine	—	35
34	Buspirone	—	299
35	Epinephrine	—	299
36	Trazodone	—	297
37	Norepinephrine Precursor of epinephrine that is secreted by	—	298
38	cbd	—	298
39	cannabidiol	—	296
40	Cabergoline	—	299
41	Methylergonovine	—	193
42	Quercetin	—	300
43	Loratadine	—	296
44	oxatomide [Supplementary Concept] structure;	—	128
45	Amlodipine	—	1,000
46	Sertraline	—	1,000
47	Domperidone	—	299
48	Phenylephrine	—	299
49	Duloxetine Hydrochloride	—	993
50	Ergotamine	—	299

About the GPCR downstream signalling Pathway

The GPCR downstream signalling pathway is catalogued in Reactome (ID: R-HSA-388396) and involves 245 genes. In the BiohacksAI corpus, 725 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADORA2B, ADORA3, ADRA1A, ADRA1B.