What compounds affect the GPCR ligand binding pathway?

670 compounds in the BiohacksAI corpus have documented interactions with genes in the GPCR ligand binding pathway (Reactome ID: R-HSA-500792). These compounds target 194 genes within this pathway.

What genes are in the GPCR ligand binding pathway?

The GPCR ligand binding pathway involves 194 genes. Key genes include: ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2.

GPCR ligand binding

REACTOME PATHWAY

Reactome: R-HSA-500792194 genes670 compounds

The GPCR ligand binding pathway (Reactome ID: R-HSA-500792) involves 194 genes and is affected by 670 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 AGTR2 APLNR APP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 C5 CALCR CASR CCKBR CCL2 CCR4 CCR6 CHRM1 CHRM2 CHRM3+164 more

Compounds Affecting GPCR ligand binding

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Aripiprazole	—	298
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Metergoline	—	144
5	Perphenazine	—	297
6	Carvedilol	—	296
7	Loxapine	—	225
8	Quetiapine Fumarate	—	994
9	Amoxapine	—	259
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
11	Mianserin	—	299
12	Fluspirilene	—	74
13	Chlorhexidine	—	299
14	Cyproheptadine	—	299
15	Fluoxetine	—	1,000
16	Dihydroergotamine	—	9
17	Dihydroergotamine	—	299
18	Nortriptyline	—	295
19	Pergolide	—	299
20	Lisuride	—	299
21	Bromocriptine	—	299
22	Yohimbine	—	299
23	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
24	Maprotiline	—	299
25	Promethazine	—	296
26	Hydroxyzine	—	298
27	Clotrimazole	—	296
28	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
29	Buspirone	—	299
30	Methysergide	—	300
31	Trazodone	—	297
32	Calcimycin	—	216
33	Hexachlorophene	—	300
34	Cabergoline	—	299
35	cbd	—	298
36	cannabidiol	—	296
37	Thioridazine	—	35
38	Methylergonovine	—	193
39	Epinephrine	—	299
40	Ergotamine	—	299
41	Norepinephrine Precursor of epinephrine that is secreted by	—	298
42	oxatomide [Supplementary Concept] structure;	—	128
43	Amlodipine	—	1,000
44	Domperidone	—	299
45	Phenylephrine	—	299
46	Tamsulosin	—	298
47	Duloxetine Hydrochloride	—	993
48	Sertraline	—	1,000
49	Disulfiram	—	297
50	Pindolol	—	299

About the GPCR ligand binding Pathway

The GPCR ligand binding pathway is catalogued in Reactome (ID: R-HSA-500792) and involves 194 genes. In the BiohacksAI corpus, 670 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D.