What compounds affect the Class A/1 (Rhodopsin-like receptors) pathway?

652 compounds in the BiohacksAI corpus have documented interactions with genes in the Class A/1 (Rhodopsin-like receptors) pathway (Reactome ID: R-HSA-373076). These compounds target 146 genes within this pathway.

What genes are in the Class A/1 (Rhodopsin-like receptors) pathway?

The Class A/1 (Rhodopsin-like receptors) pathway involves 146 genes. Key genes include: ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2.

Class A/1 (Rhodopsin-like receptors)

REACTOME PATHWAY

Reactome: R-HSA-373076146 genes652 compounds

The Class A/1 (Rhodopsin-like receptors) pathway (Reactome ID: R-HSA-373076) involves 146 genes and is affected by 652 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 AGTR2 APLNR APP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 C5 CCKBR CCL2 CCR4 CCR6 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5+116 more

Compounds Affecting Class A/1 (Rhodopsin-like receptors)

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Metergoline	—	144
4	Carvedilol	—	296
5	Perphenazine	—	297
6	Loxapine	—	225
7	Quetiapine Fumarate	—	994
8	Amoxapine	—	259
9	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
10	Mianserin	—	299
11	Fluspirilene	—	74
12	Chlorhexidine	—	299
13	Cyproheptadine	—	299
14	Fluoxetine	—	1,000
15	Dihydroergotamine	—	299
16	Nortriptyline	—	295
17	Pergolide	—	299
18	Lisuride	—	299
19	Dihydroergotamine	—	9
20	Bromocriptine	—	299
21	Yohimbine	—	299
22	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
23	Maprotiline	—	299
24	Promethazine	—	296
25	Hydroxyzine	—	298
26	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
27	Buspirone	—	299
28	Methysergide	—	300
29	Trazodone	—	297
30	Clotrimazole	—	296
31	Hexachlorophene	—	300
32	Cabergoline	—	299
33	cbd	—	298
34	cannabidiol	—	296
35	Thioridazine	—	35
36	Calcimycin	—	216
37	Methylergonovine	—	193
38	Epinephrine	—	299
39	Ergotamine	—	299
40	Norepinephrine Precursor of epinephrine that is secreted by	—	298
41	oxatomide [Supplementary Concept] structure;	—	128
42	Amlodipine	—	1,000
43	Domperidone	—	299
44	Phenylephrine	—	299
45	Tamsulosin	—	298
46	Duloxetine Hydrochloride	—	993
47	Sertraline	—	1,000
48	Disulfiram	—	297
49	Pindolol	—	299
50	Meclizine	—	121

About the Class A/1 (Rhodopsin-like receptors) Pathway

The Class A/1 (Rhodopsin-like receptors) pathway is catalogued in Reactome (ID: R-HSA-373076) and involves 146 genes. In the BiohacksAI corpus, 652 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D.