What compounds affect the Amine ligand-binding receptors pathway?

434 compounds in the BiohacksAI corpus have documented interactions with genes in the Amine ligand-binding receptors pathway (Reactome ID: R-HSA-375280). These compounds target 32 genes within this pathway.

What genes are in the Amine ligand-binding receptors pathway?

The Amine ligand-binding receptors pathway involves 32 genes. Key genes include: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1.

Amine ligand-binding receptors

REACTOME PATHWAY

Reactome: R-HSA-37528032 genes434 compounds

The Amine ligand-binding receptors pathway (Reactome ID: R-HSA-375280) involves 32 genes and is affected by 434 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 DRD1 DRD2 DRD3 DRD4 DRD5 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1E HTR2A HTR2B HTR2C HTR4 HTR6+2 more

Compounds Affecting Amine ligand-binding receptors

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Loxapine	—	225
3	Metergoline	—	144
4	Quetiapine Fumarate	—	994
5	Amoxapine	—	259
6	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
7	Mianserin	—	299
8	Cyproheptadine	—	299
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Nortriptyline	—	295
11	Pergolide	—	299
12	Lisuride	—	299
13	Carvedilol	—	296
14	Dihydroergotamine	—	299
15	Perphenazine	—	297
16	Bromocriptine	—	299
17	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
18	Yohimbine	—	299
19	Fluoxetine	—	1,000
20	Promethazine	—	296
21	Hydroxyzine	—	298
22	Dihydroergotamine	—	9
23	Maprotiline	—	299
24	Buspirone	—	299
25	Methysergide	—	300
26	Chlorhexidine	—	299
27	Cabergoline	—	299
28	Trazodone	—	297
29	Methylergonovine	—	193
30	Fluspirilene	—	74
31	Ergotamine	—	299
32	Phenylephrine	—	299
33	Tamsulosin	—	298
34	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
35	Amlodipine	—	1,000
36	Domperidone	—	299
37	Epinephrine	—	299
38	oxatomide [Supplementary Concept] structure;	—	128
39	protriptyline	—	296
40	Oxymetazoline	—	298
41	Butaclamol	—	300
42	Pramipexole	—	297
43	Duloxetine Hydrochloride	—	993
44	Dihydroergocornine	—	65
45	Norepinephrine Precursor of epinephrine that is secreted by	—	298
46	Nicergoline	—	300
47	Piribedil	—	300
48	lidoflazine	—	278
49	Pindolol	—	299
50	Meclizine	—	121

About the Amine ligand-binding receptors Pathway

The Amine ligand-binding receptors pathway is catalogued in Reactome (ID: R-HSA-375280) and involves 32 genes. In the BiohacksAI corpus, 434 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B.