What genes are in the Senescence-Associated Secretory Phenotype (SASP) pathway?

The Senescence-Associated Secretory Phenotype (SASP) pathway involves 19 genes. Key genes include: CCNA1, CDK2, CDK4, CDK6, CXCL8, EHMT1, EHMT2, FOS, IL6, JUN.

Senescence-Associated Secretory Phenotype (SASP)

Q: What compounds affect the Senescence-Associated Secretory Phenotype (SASP) pathway?

460 compounds in the BiohacksAI corpus have documented interactions with genes in the Senescence-Associated Secretory Phenotype (SASP) pathway (Reactome ID: R-HSA-2559582). These compounds target 19 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-255958219 genes460 compounds

The Senescence-Associated Secretory Phenotype (SASP) pathway (Reactome ID: R-HSA-2559582) involves 19 genes and is affected by 460 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CDK2 CDK4 CDK6 CXCL8 EHMT1 EHMT2 FOS IL6 JUN MAPK1 MAPK3 MAPK7 NFKB1 RELA RPS6KA1 RPS6KA2 RPS6KA3 STAT3

Compounds Affecting Senescence-Associated Secretory Phenotype (SASP)

#	Compound	Targets Hit	Studies
1	Budesonide	—	1,000
2	Prednisolone	—	1,000
3	Azithromycin	—	1,000
4	Sertraline	—	1,000
5	Fluoxetine	—	1,001
6	Progesterone	—	496
7	Celecoxib	—	487
8	Glutathione	—	499
9	Trifluridine	—	295
10	Loratadine	—	296
11	Salmeterol Xinafoate	—	227
12	Dimenhydrinate	—	294
13	Thioctic Acid	—	452
14	Domperidone	—	299
15	Gemfibrozil	—	297
16	DEAD-box RNA Helicases	—	169
17	Nisoldipine	—	297
18	Resveratrol	—	496
19	Lumefantrine	—	299
20	Voriconazole	—	299
21	Crizotinib	—	298
22	Hydrocortisone	—	299
23	Dacarbazine	—	299
24	Fluvoxamine	—	297
25	Sorafenib	—	300
26	Norepinephrine Precursor of epinephrine that is secreted by	—	298
27	Mianserin	—	299
28	Clotrimazole	—	296
29	Bortezomib	—	300
30	Quercetin	—	485
31	trametinib	—	296
32	Fenofibrate	—	297
33	Medroxyprogesterone Acetate	—	299
34	Vitamin	—	295
35	Ethinyl Estradiol	—	300
36	Triamcinolone	—	300
37	Maprotiline	—	299
38	Dihydrotestosterone	—	300
39	Chlormadinone Acetate	—	300
40	Colchicine	—	300
41	Taurine	—	486
42	Cinnarizine	—	299
43	Oxyphenbutazone	—	300
44	Fingolimod Hydrochloride	—	56
45	Bupranolol	—	291
46	fisetin	—	199
47	Promethazine	—	121
48	Lynestrenol	—	299
49	Clofibrate	—	299
50	Cyproheptadine	—	299

About the Senescence-Associated Secretory Phenotype (SASP) Pathway

The Senescence-Associated Secretory Phenotype (SASP) pathway is catalogued in Reactome (ID: R-HSA-2559582) and involves 19 genes. In the BiohacksAI corpus, 460 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CDK2, CDK4, CDK6, CXCL8.